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Chromatin challenges during DNA replication and repair.
Groth A, Rocha W, Verreault A, Almouzni G. Groth A, et al. Cell. 2007 Feb 23;128(4):721-33. doi: 10.1016/j.cell.2007.01.030. Cell. 2007. PMID: 17320509 Review.
To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. ...
To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and m …
Regulation of replication fork progression through histone supply and demand.
Groth A, Corpet A, Cook AJ, Roche D, Bartek J, Lukas J, Almouzni G. Groth A, et al. Science. 2007 Dec 21;318(5858):1928-31. doi: 10.1126/science.1148992. Science. 2007. PMID: 18096807
Here, we characterize a complex in which the human histone chaperone Asf1 and MCM2-7, the putative replicative helicase, are connected through a histone H3-H4 bridge. ...We propose that Asf1, as a histone acceptor and donor, handles parental and new histones …
Here, we characterize a complex in which the human histone chaperone Asf1 and MCM2-7, the putative replicative helicase, are connecte …
Chromatin replication and epigenome maintenance.
Alabert C, Groth A. Alabert C, et al. Nat Rev Mol Cell Biol. 2012 Feb 23;13(3):153-67. doi: 10.1038/nrm3288. Nat Rev Mol Cell Biol. 2012. PMID: 22358331 Review.
Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking place throughout the cell cycle. ...
Specialized replication-coupled mechanisms assemble new DNA into chromatin, but epigenome maintenance is a continuous process taking …
Human Asf1 regulates the flow of S phase histones during replicational stress.
Groth A, Ray-Gallet D, Quivy JP, Lukas J, Bartek J, Almouzni G. Groth A, et al. Mol Cell. 2005 Jan 21;17(2):301-11. doi: 10.1016/j.molcel.2004.12.018. Mol Cell. 2005. PMID: 15664198
Together, these data suggest that hAsf1 provides the cells with a buffering system for histone excess generated in response to stalled replication and explains how mammalian cells maintain a critical "active" histone pool available for deposition during recovery fro …
Together, these data suggest that hAsf1 provides the cells with a buffering system for histone excess generated in response to stalle …
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N. Hoffmann S, et al. J Cell Biol. 2016 Jan 4;212(1):63-75. doi: 10.1083/jcb.201506071. Epub 2015 Dec 28. J Cell Biol. 2016. PMID: 26711499 Free PMC article.
Proliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central role as a platform for recruitment of genome surveillance and DNA repair factors to replication forks, allowing cells to mitigate the threats to genome stability …
Proliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central role as a platform for …
Transcription Restart Establishes Chromatin Accessibility after DNA Replication.
Stewart-Morgan KR, Reverón-Gómez N, Groth A. Stewart-Morgan KR, et al. Mol Cell. 2019 Jul 25;75(2):284-297.e6. doi: 10.1016/j.molcel.2019.04.033. Epub 2019 May 21. Mol Cell. 2019. PMID: 31126739
Here we develop a replication-coupled assay for transposase-accessible chromatin (repli-ATAC-seq) to investigate active chromatin restoration post-replication in mouse embryonic stem cells. ...Collectively, this establishes a central role for transcription in overco …
Here we develop a replication-coupled assay for transposase-accessible chromatin (repli-ATAC-seq) to investigate active chromatin res …
Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication.
Reverón-Gómez N, González-Aguilera C, Stewart-Morgan KR, Petryk N, Flury V, Graziano S, Johansen JV, Jakobsen JS, Alabert C, Groth A. Reverón-Gómez N, et al. Mol Cell. 2018 Oct 18;72(2):239-249.e5. doi: 10.1016/j.molcel.2018.08.010. Epub 2018 Aug 23. Mol Cell. 2018. PMID: 30146316 Free PMC article.
Chromatin Replication and Histone Dynamics.
Alabert C, Jasencakova Z, Groth A. Alabert C, et al. Adv Exp Med Biol. 2017;1042:311-333. doi: 10.1007/978-981-10-6955-0_15. Adv Exp Med Biol. 2017. PMID: 29357065 Review.
Therefore, how specific chromatin structures are restored on newly synthesized DNA and transmitted through cell division remains a central question to understand cell fate choices and self-renewal. ...We reveal how specialized replication-coupled mechanisms rapidly assembl …
Therefore, how specific chromatin structures are restored on newly synthesized DNA and transmitted through cell division remains a ce …
Histone chaperone networks shaping chromatin function.
Hammond CM, Strømme CB, Huang H, Patel DJ, Groth A. Hammond CM, et al. Nat Rev Mol Cell Biol. 2017 Mar;18(3):141-158. doi: 10.1038/nrm.2016.159. Epub 2017 Jan 5. Nat Rev Mol Cell Biol. 2017. PMID: 28053344 Free PMC article. Review.
In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal processes, including gene expression, chromosome segregation and genome replication and repair. ...
In this way, the chaperoning of soluble histones is a key determinant of histone availability and fate, which affects all chromosomal …
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reverón-Gómez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel DJ, Groth A. Saredi G, et al. Nature. 2016 Jun 30;534(7609):714-718. doi: 10.1038/nature18312. Epub 2016 Jun 22. Nature. 2016. PMID: 27338793 Free PMC article.
Here we reveal that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the human TONSL–MMS22L homologous recombination complex. ...Together, these data reveal a histone-reader-based mechanism for recognizing t …
Here we reveal that new histones incorporated during DNA replication provide a signature of post-replicative chromatin, read by the h …
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