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Excess of heme induces tissue factor-dependent activation of coagulation in mice.
Sparkenbaugh EM, Chantrathammachart P, Wang S, Jonas W, Kirchhofer D, Gailani D, Gruber A, Kasthuri R, Key NS, Mackman N, Pawlinski R. Sparkenbaugh EM, et al. Among authors: gruber a. Haematologica. 2015 Mar;100(3):308-14. doi: 10.3324/haematol.2014.114728. Epub 2015 Jan 16. Haematologica. 2015. PMID: 25596265 Free PMC article.
Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension.
Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P. Kossmann S, et al. Among authors: gruber a. Sci Transl Med. 2017 Feb 1;9(375):eaah4923. doi: 10.1126/scitranslmed.aah4923. Sci Transl Med. 2017. PMID: 28148841
Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.
Kamikubo Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale AJ, Krishnaswamy S, Gruber A, Østergaard H, Petersen LC, Ruf W, Ruggeri ZM. Kamikubo Y, et al. Among authors: gruber a. Blood. 2017 Oct 5;130(14):1661-1670. doi: 10.1182/blood-2017-02-767079. Epub 2017 Jul 20. Blood. 2017. PMID: 28729433 Free PMC article.
Pharmacological targeting of coagulation factor XI mitigates the development of experimental atherosclerosis in low-density lipoprotein receptor-deficient mice.
Ngo ATP, Jordan KR, Mueller PA, Hagen MW, Reitsma SE, Puy C, Revenko AS, Lorentz CU, Tucker EI, Cheng Q, Hinds MT, Fazio S, Monia BP, Gailani D, Gruber A, Tavori H, McCarty OJT. Ngo ATP, et al. Among authors: gruber a. J Thromb Haemost. 2021 Apr;19(4):1001-1017. doi: 10.1111/jth.15236. Epub 2021 Feb 10. J Thromb Haemost. 2021. PMID: 33421301 Free PMC article.
1,235 results