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Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Ostertag D, Amundson KK, Lopez Espinoza F, Martin B, Buckley T, Galvão da Silva AP, Lin AH, Valenta DT, Perez OD, Ibañez CE, Chen CI, Pettersson PL, Burnett R, Daublebsky V, Hlavaty J, Gunzburg W, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. Ostertag D, et al. Among authors: gruber he. Neuro Oncol. 2012 Feb;14(2):145-59. doi: 10.1093/neuonc/nor199. Epub 2011 Nov 9. Neuro Oncol. 2012. PMID: 22070930 Free PMC article.
Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene.
Lin AH, Liu Y, Burrascano C, Cunanan K, Logg CR, Robbins JM, Kasahara N, Gruber H, Ibañez C, Jolly DJ. Lin AH, et al. Hum Gene Ther Methods. 2016 Apr;27(2):59-70. doi: 10.1089/hgtb.2015.131. Epub 2016 Feb 26. Hum Gene Ther Methods. 2016. PMID: 26918465 Free PMC article.
Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Huang TT, Hlavaty J, Ostertag D, Espinoza FL, Martin B, Petznek H, Rodriguez-Aguirre M, Ibañez CE, Kasahara N, Gunzburg W, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Huang TT, et al. Among authors: gruber he. Cancer Gene Ther. 2013 Oct;20(10):544-51. doi: 10.1038/cgt.2013.51. Epub 2013 Aug 23. Cancer Gene Ther. 2013. PMID: 23969884
Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ. Perez OD, et al. Among authors: gruber he. Mol Ther. 2012 Sep;20(9):1689-98. doi: 10.1038/mt.2012.83. Epub 2012 May 1. Mol Ther. 2012. PMID: 22547150 Free PMC article.
Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. Takahashi M, et al. Among authors: gruber he. Cancer Gene Ther. 2014 Oct;21(10):405-410. doi: 10.1038/cgt.2014.38. Epub 2014 Oct 10. Cancer Gene Ther. 2014. PMID: 25301172 Free PMC article.
Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.
Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Huang TT, et al. Among authors: gruber he. Hum Gene Ther. 2015 Feb;26(2):82-93. doi: 10.1089/hum.2014.100. Epub 2015 Jan 19. Hum Gene Ther. 2015. PMID: 25419577 Free PMC article.
293 results