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pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis.
Kremer D, Gruchot J, Weyers V, Oldemeier L, Göttle P, Healy L, Ho Jang J, Kang T Xu Y, Volsko C, Dutta R, Trapp BD, Perron H, Hartung HP, Küry P. Kremer D, et al. Among authors: gruchot j. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15216-15225. doi: 10.1073/pnas.1901283116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213545 Free PMC article.
Meeting report: "Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer", Lyon, France, november 5th and 6th 2019 - an MS scientist's digest.
Kremer D, Weyers V, Gruchot J, Göttle P, Hartung HP, Perron H, Küry P. Kremer D, et al. Among authors: gruchot j. Mult Scler Relat Disord. 2020 Jul;42:102068. doi: 10.1016/j.msard.2020.102068. Epub 2020 Apr 8. Mult Scler Relat Disord. 2020. PMID: 32302965
Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans.
Fleischer V, Gonzalez-Escamilla G, Ciolac D, Albrecht P, Küry P, Gruchot J, Dietrich M, Hecker C, Müntefering T, Bock S, Oshaghi M, Radetz A, Cerina M, Krämer J, Wachsmuth L, Faber C, Lassmann H, Ruck T, Meuth SG, Muthuraman M, Groppa S. Fleischer V, et al. Among authors: gruchot j. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2025000118. doi: 10.1073/pnas.2025000118. Proc Natl Acad Sci U S A. 2021. PMID: 34479997 Free PMC article.
Increased Remyelination and Proregenerative Microglia Under Siponimod Therapy in Mechanistic Models.
Dietrich M, Hecker C, Martin E, Langui D, Gliem M, Stankoff B, Lubetzki C, Gruchot J, Göttle P, Issberner A, Nasiri M, Ramseier P, Beerli C, Tisserand S, Beckmann N, Shimshek D, Petzsch P, Akbar D, Levkau B, Stark H, Köhrer K, Hartung HP, Küry P, Meuth SG, Bigaud M, Zalc B, Albrecht P. Dietrich M, et al. Among authors: gruchot j. Neurol Neuroimmunol Neuroinflamm. 2022 Mar 30;9(3):e1161. doi: 10.1212/NXI.0000000000001161. Print 2022 May. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 35354603 Free PMC article.
18 results