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Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.
Magiera-Mularz K, Skalniak L, Zak KM, Musielak B, Rudzinska-Szostak E, Berlicki Ł, Kocik J, Grudnik P, Sala D, Zarganes-Tzitzikas T, Shaabani S, Dömling A, Dubin G, Holak TA. Magiera-Mularz K, et al. Among authors: grudnik p. Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13732-13735. doi: 10.1002/anie.201707707. Epub 2017 Sep 26. Angew Chem Int Ed Engl. 2017. PMID: 28881104 Free PMC article.
Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.
Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA. Skalniak L, et al. Among authors: grudnik p. Oncotarget. 2017 Aug 7;8(42):72167-72181. doi: 10.18632/oncotarget.20050. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069777 Free PMC article.
Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2.
Twarda-Clapa A, Labuzek B, Krzemien D, Musielak B, Grudnik P, Dubin G, Holak TA. Twarda-Clapa A, et al. Among authors: grudnik p. Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):695-701. doi: 10.1107/S2059798318007271. Epub 2018 Jun 27. Acta Crystallogr D Struct Biol. 2018. PMID: 29968679
Human and mouse PD-L1: similar molecular structure, but different druggability profiles.
Magiera-Mularz K, Kocik J, Musielak B, Plewka J, Sala D, Machula M, Grudnik P, Hajduk M, Czepiel M, Siedlar M, Holak TA, Skalniak L. Magiera-Mularz K, et al. Among authors: grudnik p. iScience. 2020 Dec 24;24(1):101960. doi: 10.1016/j.isci.2020.101960. eCollection 2021 Jan 22. iScience. 2020. PMID: 33437940 Free PMC article.
32 results