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The amino-terminal domain of the transcription termination factor TTF-I causes protein oligomerization and inhibition of DNA binding.
Sander EE, Mason SW, Munz C, Grummt I. Sander EE, et al. Nucleic Acids Res. 1996 Oct 1;24(19):3677-84. doi: 10.1093/nar/24.19.3677. Nucleic Acids Res. 1996. PMID: 8871544 Free PMC article.
The transcription termination factor TTF-I binds specifically to an 18 bp DNA element in the murine ribosomal gene spacer and mediates termination of RNA polymerase I transcription. ...Thus, in contrast to previous studies suggesting that activation of TTF-I
The transcription termination factor TTF-I binds specifically to an 18 bp DNA element in the murine ribosomal gene spacer and mediate …
Detection of RNA-DNA binding sites in long noncoding RNAs.
Kuo CC, Hänzelmann S, Sentürk Cetin N, Frank S, Zajzon B, Derks JP, Akhade VS, Ahuja G, Kanduri C, Grummt I, Kurian L, Costa IG. Kuo CC, et al. Among authors: grummt i. Nucleic Acids Res. 2019 Apr 8;47(6):e32. doi: 10.1093/nar/gkz037. Nucleic Acids Res. 2019. PMID: 30698727 Free PMC article.
Isolation and genome-wide characterization of cellular DNA:RNA triplex structures.
Sentürk Cetin N, Kuo CC, Ribarska T, Li R, Costa IG, Grummt I. Sentürk Cetin N, et al. Among authors: grummt i. Nucleic Acids Res. 2019 Mar 18;47(5):2306-2321. doi: 10.1093/nar/gky1305. Nucleic Acids Res. 2019. PMID: 30605520 Free PMC article.
Development of a species-specific RNA polymerase I-based shRNA expression vector.
Brenz Verca MS, Weber P, Mayer C, Graf C, Refojo D, Kühn R, Grummt I, Lutz B. Brenz Verca MS, et al. Nucleic Acids Res. 2007;35(2):e10. doi: 10.1093/nar/gkl1045. Epub 2006 Dec 7. Nucleic Acids Res. 2007. PMID: 17158154 Free PMC article.
We developed an alternative vector for siRNA/shRNA expression, using a mouse RNA polymerase I (Pol I) promoter. Pol I-dependent transcription serves in cells for production of ribosomal RNA (rRNA), and as such, is ubiquitously and stably active in different c …
We developed an alternative vector for siRNA/shRNA expression, using a mouse RNA polymerase I (Pol I) promoter. Pol I-d …
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells.
Espada J, Ballestar E, Santoro R, Fraga MF, Villar-Garea A, Németh A, Lopez-Serra L, Ropero S, Aranda A, Orozco H, Moreno V, Juarranz A, Stockert JC, Längst G, Grummt I, Bickmore W, Esteller M. Espada J, et al. Nucleic Acids Res. 2007;35(7):2191-8. doi: 10.1093/nar/gkm118. Epub 2007 Mar 13. Nucleic Acids Res. 2007. PMID: 17355984 Free PMC article.
Epigenetic control of RNA polymerase I transcription in mammalian cells.
Grummt I, Längst G. Grummt I, et al. Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):393-404. doi: 10.1016/j.bbagrm.2012.10.004. Epub 2012 Oct 12. Biochim Biophys Acta. 2013. PMID: 23063748 Review.
GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I, Niehrs C. Arab K, et al. Among authors: grummt i. Nat Genet. 2019 Feb;51(2):217-223. doi: 10.1038/s41588-018-0306-6. Epub 2019 Jan 7. Nat Genet. 2019. PMID: 30617255 Free PMC article.
Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.
Diermeier SD, Németh A, Rehli M, Grummt I, Längst G. Diermeier SD, et al. PLoS Genet. 2013;9(9):e1003786. doi: 10.1371/journal.pgen.1003786. Epub 2013 Sep 12. PLoS Genet. 2013. PMID: 24068958 Free PMC article.
On chromatin templates, but not on free rDNA, clustered binding sites promote cooperative binding of TTF-I, loading TTF-I to the downstream terminators before it binds to the rDNA promoter. Interaction of TTF-I with target sites upstream and downstream of the …
On chromatin templates, but not on free rDNA, clustered binding sites promote cooperative binding of TTF-I, loading TTF-I to t …
Identification of novel functional TBP-binding sites and general factor repertoires.
Denissov S, van Driel M, Voit R, Hekkelman M, Hulsen T, Hernandez N, Grummt I, Wehrens R, Stunnenberg H. Denissov S, et al. EMBO J. 2007 Feb 21;26(4):944-54. doi: 10.1038/sj.emboj.7601550. Epub 2007 Feb 1. EMBO J. 2007. PMID: 17268553 Free PMC article.
Integrated analysis of the ChIP-on-chip data and functional studies revealed that TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. ...
Integrated analysis of the ChIP-on-chip data and functional studies revealed that TAF12 hitherto regarded as RNA polymerase II (RNAP II)-spe …
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