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TFIIS binds to mouse RNA polymerase I and stimulates transcript elongation and hydrolytic cleavage of nascent rRNA.
Schnapp G, Graveley BR, Grummt I. Schnapp G, et al. Mol Gen Genet. 1996 Sep 25;252(4):412-9. doi: 10.1007/BF02173006. Mol Gen Genet. 1996. PMID: 8879242
Efficient transcription elongation by RNA polymerase I (Pol I) requires a specific Pol I-associated factor, termed TIF-IC. Here we show that TFIIS, a factor that has previously been shown to promote read-through past many types of blocks to elongation by RNA …
Efficient transcription elongation by RNA polymerase I (Pol I) requires a specific Pol I-associated factor, termed TIF- …
Development of a species-specific RNA polymerase I-based shRNA expression vector.
Brenz Verca MS, Weber P, Mayer C, Graf C, Refojo D, Kühn R, Grummt I, Lutz B. Brenz Verca MS, et al. Nucleic Acids Res. 2007;35(2):e10. doi: 10.1093/nar/gkl1045. Epub 2006 Dec 7. Nucleic Acids Res. 2007. PMID: 17158154 Free PMC article.
We developed an alternative vector for siRNA/shRNA expression, using a mouse RNA polymerase I (Pol I) promoter. Pol I-dependent transcription serves in cells for production of ribosomal RNA (rRNA), and as such, is ubiquitously and stably active in different c …
We developed an alternative vector for siRNA/shRNA expression, using a mouse RNA polymerase I (Pol I) promoter. Pol I-d …
SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.
Chen S, Blank MF, Iyer A, Huang B, Wang L, Grummt I, Voit R. Chen S, et al. Nat Commun. 2016 Feb 12;7:10734. doi: 10.1038/ncomms10734. Nat Commun. 2016. PMID: 26867678 Free PMC article.
Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-ribosomal RNA (rRNA) and promotes rRNA synthesis. ...
Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-ribosomal RNA (rRNA) and promote …
Epigenetic control of RNA polymerase I transcription in mammalian cells.
Grummt I, Längst G. Grummt I, et al. Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):393-404. doi: 10.1016/j.bbagrm.2012.10.004. Epub 2012 Oct 12. Biochim Biophys Acta. 2013. PMID: 23063748 Review.
GADD45A binds R-loops and recruits TET1 to CpG island promoters.
Arab K, Karaulanov E, Musheev M, Trnka P, Schäfer A, Grummt I, Niehrs C. Arab K, et al. Among authors: grummt i. Nat Genet. 2019 Feb;51(2):217-223. doi: 10.1038/s41588-018-0306-6. Epub 2019 Jan 7. Nat Genet. 2019. PMID: 30617255 Free PMC article.
LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure.
Postepska-Igielska A, Giwojna A, Gasri-Plotnitsky L, Schmitt N, Dold A, Ginsberg D, Grummt I. Postepska-Igielska A, et al. Mol Cell. 2015 Nov 19;60(4):626-36. doi: 10.1016/j.molcel.2015.10.001. Mol Cell. 2015. PMID: 26590717
Alu element-containing RNAs maintain nucleolar structure and function.
Caudron-Herger M, Pankert T, Seiler J, Németh A, Voit R, Grummt I, Rippe K. Caudron-Herger M, et al. EMBO J. 2015 Nov 12;34(22):2758-74. doi: 10.15252/embj.201591458. Epub 2015 Oct 13. EMBO J. 2015. PMID: 26464461 Free PMC article.
Antisense-oligo-mediated depletion of aluRNAs or drug-induced inhibition of RNA polymerase II activity disrupted nucleolar structure and impaired RNA polymerase I-dependent transcription of rRNA genes. ...Our study suggests an aluRNA-based mechanism that links RNA polymera …
Antisense-oligo-mediated depletion of aluRNAs or drug-induced inhibition of RNA polymerase II activity disrupted nucleolar structure and imp …
Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes.
Grummt I. Grummt I. Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R21-7. doi: 10.1093/hmg/ddm020. Hum Mol Genet. 2007. PMID: 17613545 Review.
The presence of two epigenetically distinct states of rRNA genes provides a unique opportunity to decipher the molecular mechanisms that establish the euchromatic, i.e. transcriptionally active, and the heterochromatic, i.e. transcriptionally silent, state of rDNA. …
The presence of two epigenetically distinct states of rRNA genes provides a unique opportunity to decipher the molecular mechanisms that est …
Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.
Voit R, Seiler J, Grummt I. Voit R, et al. PLoS Genet. 2015 May 29;11(5):e1005246. doi: 10.1371/journal.pgen.1005246. eCollection 2015 May. PLoS Genet. 2015. PMID: 26023773 Free PMC article.
Mitotic repression of rRNA synthesis requires inactivation of the RNA polymerase I (Pol I)-specific transcription factor SL1 by Cdk1/cyclin B-dependent phosphorylation of TAF(I)110 (TBP-associated factor 110) at a single threonine residue (T852). ...Inhibitio …
Mitotic repression of rRNA synthesis requires inactivation of the RNA polymerase I (Pol I)-specific transcription factor SL1 b …
AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply.
Hoppe S, Bierhoff H, Cado I, Weber A, Tiebe M, Grummt I, Voit R. Hoppe S, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17781-6. doi: 10.1073/pnas.0909873106. Epub 2009 Oct 6. Proc Natl Acad Sci U S A. 2009. PMID: 19815529 Free PMC article.
Here, we show that AMPK down-regulates rRNA synthesis under glucose restriction by phosphorylating the RNA polymerase I (Pol I)-associated transcription factor TIF-IA at a single serine residue (Ser-635). ...Mutation of Ser-635 compromises down-regulation of Pol …
Here, we show that AMPK down-regulates rRNA synthesis under glucose restriction by phosphorylating the RNA polymerase I (Pol I
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