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Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
Grundmann O, Nakajima J, Seo S, Butterweck V. Grundmann O, et al. J Ethnopharmacol. 2007 Apr 4;110(3):406-11. doi: 10.1016/j.jep.2006.09.035. Epub 2006 Oct 13. J Ethnopharmacol. 2007. PMID: 17101250
A single treatment of AV extract markedly increased the percentage time spent on and the number of entries into the open arms of the EPM in doses of 30 and 125 mg/kg p.o., respectively. This effect was comparable to that of the benzodiazepine diazepam (1.5 mg/kg p.o
A single treatment of AV extract markedly increased the percentage time spent on and the number of entries into the open arms of the EPM in …
Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice.
Grundmann O, Kelber O, Butterweck V. Grundmann O, et al. Planta Med. 2006 Dec;72(15):1366-71. doi: 10.1055/s-2006-951710. Epub 2006 Oct 18. Planta Med. 2006. PMID: 17051457
The flavonoids hyperoside, isoquercitrin and quercitrin (all at 0.6 mg/kg, p. o.) and rutin (1 mg/kg, p. o.) only partially blocked OF-induced hyperthermia. If compared to all other flavonoids, the quercetin 3-O-glucuronide miquelianin (1.2 mg/kg, p. o
The flavonoids hyperoside, isoquercitrin and quercitrin (all at 0.6 mg/kg, p. o.) and rutin (1 mg/kg, p. o.) only partially bl …
Kaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in mice.
Grundmann O, Nakajima J, Kamata K, Seo S, Butterweck V. Grundmann O, et al. Phytomedicine. 2009 Apr;16(4):295-302. doi: 10.1016/j.phymed.2008.12.020. Phytomedicine. 2009. PMID: 19303276
A single treatment of AV extract markedly increased the percentage time spent on the open arms of the EPM in two distinct concentration ranges of 22.5-30 and 100-125 mg/kg p.o., respectively, indicating a putative anxiolytic-like activity. ...Through further separation of …
A single treatment of AV extract markedly increased the percentage time spent on the open arms of the EPM in two distinct concentration rang …
Mechanism of St. John's wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system.
Grundmann O, Lv Y, Kelber O, Butterweck V. Grundmann O, et al. Neuropharmacology. 2010 Mar-Apr;58(4-5):767-73. doi: 10.1016/j.neuropharm.2009.12.014. Epub 2009 Dec 28. Neuropharmacology. 2010. PMID: 20036263
The results show that stressed animals decreased in open field activity compared to unstressed animals, which could be reversed by fluoxetine (10mg/kg, p.o.) and SJW (125-750mg/kg, p.o.) treatment. ...
The results show that stressed animals decreased in open field activity compared to unstressed animals, which could be reversed by fluoxetin …
Assessment of gonadotropins and testosterone hormone levels in regular Mitragyna speciosa (Korth.) users.
Singh D, Murugaiyah V, Hamid SBS, Kasinather V, Chan MSA, Ho ETW, Grundmann O, Chear NJY, Mansor SM. Singh D, et al. J Ethnopharmacol. 2018 Jul 15;221:30-36. doi: 10.1016/j.jep.2018.04.005. Epub 2018 Apr 5. J Ethnopharmacol. 2018. PMID: 29626673
Self-reported prevalence and severity of opioid and kratom (Mitragyna speciosa korth.) side effects.
Saref A, Suraya S, Singh D, Grundmann O, Narayanan S, Swogger MT, Prozialeck WC, Boyer E, Chear NJY, Balasingam V. Saref A, et al. J Ethnopharmacol. 2019 Jun 28;238:111876. doi: 10.1016/j.jep.2019.111876. Epub 2019 Apr 20. J Ethnopharmacol. 2019. PMID: 31014959
Salvia divinorum and salvinorin A: an update on pharmacology and analytical methodology.
Grundmann O, Phipps SM, Zadezensky I, Butterweck V. Grundmann O, et al. Planta Med. 2007 Aug;73(10):1039-46. doi: 10.1055/s-2007-981566. Epub 2007 Jul 12. Planta Med. 2007. PMID: 17628834 Review.
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