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Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K, Murphy MP. Martin JL, et al. Among authors: gruszczyk av. Nat Metab. 2019 Sep 30;1:966-974. doi: 10.1038/s42255-019-0115-y. Nat Metab. 2019. PMID: 32395697 Free PMC article.
Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.
Martin JL, Gruszczyk AV, Beach TE, Murphy MP, Saeb-Parsy K. Martin JL, et al. Among authors: gruszczyk av. Pediatr Nephrol. 2019 Jul;34(7):1167-1174. doi: 10.1007/s00467-018-3984-5. Epub 2018 Jun 2. Pediatr Nephrol. 2019. PMID: 29860579 Free PMC article. Review.
Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP. Hinchy EC, et al. Among authors: gruszczyk av. J Biol Chem. 2018 Nov 2;293(44):17208-17217. doi: 10.1074/jbc.RA118.002579. Epub 2018 Sep 19. J Biol Chem. 2018. PMID: 30232152 Free PMC article.
Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.
Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T. Antonucci S, et al. Among authors: gruszczyk av. Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4. Free Radic Biol Med. 2019. PMID: 30731114 Free PMC article.
Mechanism of succinate efflux upon reperfusion of the ischaemic heart.
Prag HA, Gruszczyk AV, Huang MM, Beach TE, Young T, Tronci L, Nikitopoulou E, Mulvey JF, Ascione R, Hadjihambi A, Shattock MJ, Pellerin L, Saeb-Parsy K, Frezza C, James AM, Krieg T, Murphy MP, Aksentijević D. Prag HA, et al. Among authors: gruszczyk av. Cardiovasc Res. 2021 Mar 21;117(4):1188-1201. doi: 10.1093/cvr/cvaa148. Cardiovasc Res. 2021. PMID: 32766828 Free PMC article.
21 results