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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Inoki K, Li Y, Zhu T, Wu J, Guan KL. Inoki K, et al. Among authors: guan kl. Nat Cell Biol. 2002 Sep;4(9):648-57. doi: 10.1038/ncb839. Nat Cell Biol. 2002. PMID: 12172553
Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK).
Pang L, Zheng CF, Guan KL, Saltiel AR. Pang L, et al. Among authors: guan kl. Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):513-9. doi: 10.1042/bj3070513. Biochem J. 1995. PMID: 7733891 Free PMC article.
However, immunoprecipitation experiments in PC-12 cells revealed that raf is not the major NGF-dependent MEK kinase [Zheng, Ohmichi, Saltiel and Guan (1994) Biochemistry 33, 5595-5599]. ...
However, immunoprecipitation experiments in PC-12 cells revealed that raf is not the major NGF-dependent MEK kinase [Zheng, Ohmichi, Saltiel …
The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus.
Guan KL. Guan KL. Cell Signal. 1994 Aug;6(6):581-9. doi: 10.1016/0898-6568(94)90041-8. Cell Signal. 1994. PMID: 7857762 Review.
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y. Guan KL, et al. Genes Dev. 1994 Dec 15;8(24):2939-52. doi: 10.1101/gad.8.24.2939. Genes Dev. 1994. PMID: 8001816
Cytoplasmic localization of the mitogen-activated protein kinase activator MEK.
Zheng CF, Guan KL. Zheng CF, et al. Among authors: guan kl. J Biol Chem. 1994 Aug 5;269(31):19947-52. J Biol Chem. 1994. PMID: 8051079
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
Zheng CF, Guan KL. Zheng CF, et al. Among authors: guan kl. EMBO J. 1994 Mar 1;13(5):1123-31. EMBO J. 1994. PMID: 8131746 Free PMC article.
Growth factor induced MEK activation is primarily mediated by an activator different from c-raf.
Zheng CF, Ohmichi M, Saltiel AR, Guan KL. Zheng CF, et al. Among authors: guan kl. Biochemistry. 1994 May 10;33(18):5595-9. doi: 10.1021/bi00184a031. Biochemistry. 1994. PMID: 8180183
Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases.
Zheng CF, Guan KL. Zheng CF, et al. Among authors: guan kl. J Biol Chem. 1993 Nov 15;268(32):23933-9. J Biol Chem. 1993. PMID: 8226933
Bacterial and viral protein tyrosine phosphatases.
Guan KL, Dixon JE. Guan KL, et al. Semin Cell Biol. 1993 Dec;4(6):389-96. doi: 10.1006/scel.1993.1046. Semin Cell Biol. 1993. PMID: 8305677 Review.
Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase.
Zheng CF, Guan KL. Zheng CF, et al. Among authors: guan kl. J Biol Chem. 1993 Aug 5;268(22):16116-9. J Biol Chem. 1993. PMID: 8344896
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