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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Mostoslavsky R, et al. Among authors: guarente l. Cell. 2006 Jan 27;124(2):315-29. doi: 10.1016/j.cell.2005.11.044. Cell. 2006. PMID: 16439206 Free article.
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B. Lombard DB, et al. Mol Cell Biol. 2007 Dec;27(24):8807-14. doi: 10.1128/MCB.01636-07. Epub 2007 Oct 8. Mol Cell Biol. 2007. PMID: 17923681 Free PMC article.
Tissue-specific regulation of SIRT1 by calorie restriction.
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Chen D, et al. Among authors: guarente l. Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11. Genes Dev. 2008. PMID: 18550784 Free PMC article.
Aging and disease: connections to sirtuins.
Donmez G, Guarente L. Donmez G, et al. Among authors: guarente l. Aging Cell. 2010 Apr;9(2):285-90. doi: 10.1111/j.1474-9726.2010.00548.x. Aging Cell. 2010. PMID: 20409078 Free article. Review.
Nucleolar localization of the Werner syndrome protein in human cells.
Marciniak RA, Lombard DB, Johnson FB, Guarente L. Marciniak RA, et al. Among authors: guarente l. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6887-92. doi: 10.1073/pnas.95.12.6887. Proc Natl Acad Sci U S A. 1998. PMID: 9618508 Free PMC article.
302 results