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SIRT1 transgenic mice show phenotypes resembling calorie restriction.
Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L. Bordone L, et al. Among authors: guarente l. Aging Cell. 2007 Dec;6(6):759-67. doi: 10.1111/j.1474-9726.2007.00335.x. Epub 2007 Sep 17. Aging Cell. 2007. PMID: 17877786 Free article.
Neurogenesis directed by Sirt1.
Libert S, Cohen D, Guarente L. Libert S, et al. Among authors: guarente l. Nat Cell Biol. 2008 Apr;10(4):373-4. doi: 10.1038/ncb0408-373. Nat Cell Biol. 2008. PMID: 18379594 Free PMC article.
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.
Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L. Chen D, et al. Among authors: guarente l. Exp Gerontol. 2008 Dec;43(12):1086-93. doi: 10.1016/j.exger.2008.08.050. Epub 2008 Aug 30. Exp Gerontol. 2008. PMID: 18799131 Free PMC article.
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L. Libert S, et al. Among authors: guarente l. Cell. 2011 Dec 23;147(7):1459-72. doi: 10.1016/j.cell.2011.10.054. Epub 2011 Dec 8. Cell. 2011. PMID: 22169038 Free PMC article.
Mammalian SIRT1 represses forkhead transcription factors.
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Motta MC, et al. Among authors: guarente l. Cell. 2004 Feb 20;116(4):551-63. doi: 10.1016/s0092-8674(04)00126-6. Cell. 2004. PMID: 14980222 Free article.
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.
Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, McDonagh T, Lemieux M, McBurney M, Szilvasi A, Easlon EJ, Lin SJ, Guarente L. Bordone L, et al. Among authors: guarente l. PLoS Biol. 2006 Feb;4(2):e31. doi: 10.1371/journal.pbio.0040031. Epub 2005 Dec 27. PLoS Biol. 2006. PMID: 16366736 Free PMC article.
302 results