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Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae.
Guarente L, Lalonde B, Gifford P, Alani E. Guarente L, et al. Cell. 1984 Feb;36(2):503-11. doi: 10.1016/0092-8674(84)90243-5. Cell. 1984. PMID: 6319028
The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts.
Hahn S, Pinkham J, Wei R, Miller R, Guarente L. Hahn S, et al. Among authors: guarente l. Mol Cell Biol. 1988 Feb;8(2):655-63. doi: 10.1128/mcb.8.2.655. Mol Cell Biol. 1988. PMID: 2832732 Free PMC article.
Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box".
Guarente L, Hoar E. Guarente L, et al. Proc Natl Acad Sci U S A. 1984 Dec;81(24):7860-4. doi: 10.1073/pnas.81.24.7860. Proc Natl Acad Sci U S A. 1984. PMID: 6096863 Free PMC article.
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site.
Guarente L, Mason T. Guarente L, et al. Cell. 1983 Apr;32(4):1279-86. doi: 10.1016/0092-8674(83)90309-4. Cell. 1983. PMID: 6301690
Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene.
Pfeifer K, Arcangioli B, Guarente L. Pfeifer K, et al. Among authors: guarente l. Cell. 1987 Apr 10;49(1):9-18. doi: 10.1016/0092-8674(87)90750-1. Cell. 1987. PMID: 3030567
Yeast HAP1 activator binds to two upstream activation sites of different sequence.
Pfeifer K, Prezant T, Guarente L. Pfeifer K, et al. Among authors: guarente l. Cell. 1987 Apr 10;49(1):19-27. doi: 10.1016/0092-8674(87)90751-3. Cell. 1987. PMID: 3030565
A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity.
Lalonde B, Arcangioli B, Guarente L. Lalonde B, et al. Among authors: guarente l. Mol Cell Biol. 1986 Dec;6(12):4690-6. doi: 10.1128/mcb.6.12.4690. Mol Cell Biol. 1986. PMID: 3025665 Free PMC article.
The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c.
Verdière J, Creusot F, Guarente L, Slonimski PP. Verdière J, et al. Among authors: guarente l. Curr Genet. 1986;10(5):339-42. doi: 10.1007/BF00418404. Curr Genet. 1986. PMID: 2832070
Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site.
Forsburg SL, Guarente L. Forsburg SL, et al. Among authors: guarente l. Mol Cell Biol. 1988 Feb;8(2):647-54. doi: 10.1128/mcb.8.2.647. Mol Cell Biol. 1988. PMID: 2832731 Free PMC article.
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.
Guarente L, Yocum RR, Gifford P. Guarente L, et al. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7410-4. doi: 10.1073/pnas.79.23.7410. Proc Natl Acad Sci U S A. 1982. PMID: 6760197 Free PMC article.
This identification was achieved by excising a 365-base-pair fragment of GAL10 leader DNA with a GAL10 proximal endpoint greater than 100 base pairs upstream of the transcriptional start site and substituting it in place of the upstream activation site of the CYC1 (iso-1-cytochro …
This identification was achieved by excising a 365-base-pair fragment of GAL10 leader DNA with a GAL10 proximal endpoint greater than 100 ba …
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