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Mitotane has a strong and a durable inducing effect on CYP3A4 activity.
van Erp NP, Guchelaar HJ, Ploeger BA, Romijn JA, Hartigh Jd, Gelderblom H. van Erp NP, et al. Among authors: guchelaar hj. Eur J Endocrinol. 2011 Apr;164(4):621-6. doi: 10.1530/EJE-10-0956. Epub 2011 Jan 10. Eur J Endocrinol. 2011. PMID: 21220434 Clinical Trial.
Influence of CYP3A4 inhibition on the steady-state pharmacokinetics of imatinib.
van Erp NP, Gelderblom H, Karlsson MO, Li J, Zhao M, Ouwerkerk J, Nortier JW, Guchelaar HJ, Baker SD, Sparreboom A. van Erp NP, et al. Among authors: guchelaar hj. Clin Cancer Res. 2007 Dec 15;13(24):7394-400. doi: 10.1158/1078-0432.CCR-07-0346. Clin Cancer Res. 2007. PMID: 18094422 Clinical Trial.
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