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Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI. Kumashiro N, et al. Hepatology. 2013 May;57(5):1763-72. doi: 10.1002/hep.26170. Epub 2013 Jan 25. Hepatology. 2013. PMID: 23175050 Free PMC article.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI. Cantley JL, et al. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302688 Free PMC article.
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance.
Kumashiro N, Beddow SA, Vatner DF, Majumdar SK, Cantley JL, Guebre-Egziabher F, Fat I, Guigni B, Jurczak MJ, Birkenfeld AL, Kahn M, Perler BK, Puchowicz MA, Manchem VP, Bhanot S, Still CD, Gerhard GS, Petersen KF, Cline GW, Shulman GI, Samuel VT. Kumashiro N, et al. Diabetes. 2013 Jul;62(7):2183-94. doi: 10.2337/db12-1311. Epub 2013 Feb 19. Diabetes. 2013. PMID: 23423574 Free PMC article.
Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
Cantley JL, Vatner DF, Galbo T, Madiraju A, Petersen M, Perry RJ, Kumashiro N, Guebre-Egziabher F, Gattu AK, Stacy MR, Dione DP, Sinusas AJ, Ragolia L, Hall CE, Manchem VP, Bhanot S, Bogan JS, Samuel VT. Cantley JL, et al. Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E773-83. doi: 10.1152/ajpendo.00148.2014. Epub 2014 Aug 26. Am J Physiol Endocrinol Metab. 2014. PMID: 25159329 Free PMC article.
Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Pesta DH, et al. Aging (Albany NY). 2015 Dec;7(12):1086-93. doi: 10.18632/aging.100854. Aging (Albany NY). 2015. PMID: 26647160 Free PMC article.
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Birkenfeld AL, et al. Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Cell Metab. 2011. PMID: 21803289 Free PMC article.
85 results