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High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding.
Proc Natl Acad Sci U S A. 2017 May 23;114(21):5461-5466. doi: 10.1073/pnas.1700557114. Epub 2017 May 11.
Proc Natl Acad Sci U S A. 2017.
PMID: 28495970
Free PMC article.
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference.
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA.
Hochstrasser ML, et al. Among authors: guegler ck.
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6618-23. doi: 10.1073/pnas.1405079111. Epub 2014 Apr 18.
Proc Natl Acad Sci U S A. 2014.
PMID: 24748111
Free PMC article.
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Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.
Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC.
Redding S, et al. Among authors: guegler ck.
Cell. 2015 Nov 5;163(4):854-65. doi: 10.1016/j.cell.2015.10.003.
Cell. 2015.
PMID: 26522594
Free PMC article.
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Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection.
Guegler CK, Laub MT.
Guegler CK, et al.
Mol Cell. 2021 Jun 3;81(11):2361-2373.e9. doi: 10.1016/j.molcel.2021.03.027. Epub 2021 Apr 9.
Mol Cell. 2021.
PMID: 33838104
Free PMC article.
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The evolution of a counter-defense mechanism in a virus constrains its host range.
Srikant S, Guegler CK, Laub MT.
Srikant S, et al. Among authors: guegler ck.
Elife. 2022 Aug 4;11:e79549. doi: 10.7554/eLife.79549.
Elife. 2022.
PMID: 35924892
Free PMC article.
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A Simple, Cost-Effective, and Robust Method for rRNA Depletion in RNA-Sequencing Studies.
Culviner PH, Guegler CK, Laub MT.
Culviner PH, et al. Among authors: guegler ck.
mBio. 2020 Apr 21;11(2):e00010-20. doi: 10.1128/mBio.00010-20.
mBio. 2020.
PMID: 32317317
Free PMC article.
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A phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin-antitoxin system.
Guegler CK, Teodoro GIC, Srikant S, Chetlapalli K, Doering CR, Ghose DA, Laub MT.
Guegler CK, et al.
Nucleic Acids Res. 2024 Feb 9;52(3):1298-1312. doi: 10.1093/nar/gkad1207.
Nucleic Acids Res. 2024.
PMID: 38117986
Free PMC article.
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