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Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes.
Burban A, Sharanek A, Guguen-Guillouzo C, Guillouzo A. Burban A, et al. Among authors: guguen guillouzo c. Free Radic Biol Med. 2018 Feb 1;115:166-178. doi: 10.1016/j.freeradbiomed.2017.11.017. Epub 2017 Dec 2. Free Radic Biol Med. 2018. PMID: 29191461
Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation.
Sharanek A, Burban A, Humbert L, Guguen-Guillouzo C, Rainteau D, Guillouzo A. Sharanek A, et al. Among authors: guguen guillouzo c. Drug Metab Dispos. 2017 Dec;45(12):1292-1303. doi: 10.1124/dmd.117.077420. Epub 2017 Sep 19. Drug Metab Dispos. 2017. PMID: 28928138
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways.
Burban A, Sharanek A, Hüe R, Gay M, Routier S, Guillouzo A, Guguen-Guillouzo C. Burban A, et al. Among authors: guguen guillouzo c. Sci Rep. 2017 May 12;7(1):1815. doi: 10.1038/s41598-017-01171-y. Sci Rep. 2017. PMID: 28500348 Free PMC article.
Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.
Al-Attrache H, Sharanek A, Burban A, Burbank M, Gicquel T, Abdel-Razzak Z, Guguen-Guillouzo C, Morel I, Guillouzo A. Al-Attrache H, et al. Among authors: guguen guillouzo c. Toxicol Lett. 2016 Sep 6;258:71-86. doi: 10.1016/j.toxlet.2016.06.008. Epub 2016 Jun 14. Toxicol Lett. 2016. PMID: 27313093 Free article.
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.
Sharanek A, Burban A, Burbank M, Le Guevel R, Li R, Guillouzo A, Guguen-Guillouzo C. Sharanek A, et al. Sci Rep. 2016 May 12;6:24709. doi: 10.1038/srep24709. Sci Rep. 2016. PMID: 27169750 Free PMC article.
Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
Burbank MG, Burban A, Sharanek A, Weaver RJ, Guguen-Guillouzo C, Guillouzo A. Burbank MG, et al. Among authors: guguen guillouzo c. Drug Metab Dispos. 2016 Nov;44(11):1780-1793. doi: 10.1124/dmd.116.071373. Epub 2016 Aug 18. Drug Metab Dispos. 2016. PMID: 27538918 Free article.
Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential.
Burban A, Sharanek A, Humbert L, Eguether T, Guguen-Guillouzo C, Rainteau D, Guillouzo A. Burban A, et al. Among authors: guguen guillouzo c. Toxicol Sci. 2019 Apr 1;168(2):474-485. doi: 10.1093/toxsci/kfz009. Toxicol Sci. 2019. PMID: 30629237 Free article.
Setup and Use of HepaRG Cells in Cholestasis Research.
Guguen-Guillouzo C, Guillouzo A. Guguen-Guillouzo C, et al. Methods Mol Biol. 2019;1981:291-312. doi: 10.1007/978-1-4939-9420-5_19. Methods Mol Biol. 2019. PMID: 31016662
Reperfusion stress induced during intermittent selective clamping accelerates rat liver regeneration through JNK pathway.
Duval H, Mbatchi SF, Grandadam S, Legendre C, Loyer P, Ribault C, Piquet-Pellorce C, Guguen-Guillouzo C, Boudjema K, Corlu A. Duval H, et al. J Hepatol. 2010 Apr;52(4):560-9. doi: 10.1016/j.jhep.2010.01.013. Epub 2010 Feb 13. J Hepatol. 2010. PMID: 20207439
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