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Proliferation of human malignant astrocytomas is dependent on Ras activation.
Guha A, Feldkamp MM, Lau N, Boss G, Pawson A. Guha A, et al. Oncogene. 1997 Dec 4;15(23):2755-65. doi: 10.1038/sj.onc.1201455. Oncogene. 1997. PMID: 9419966
Stimulation of PDGFR's and EGFR's induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2, suggesting a mechanism by which Ras may be activated in human malignant astrocytoma cells. ...
Stimulation of PDGFR's and EGFR's induced tyrosine phosphorylation of the Shc adaptor protein and its association with Grb2, suggesting a
Detection of activated platelet-derived growth factor receptors in human meningioma.
Shamah SM, Alberta JA, Giannobile WV, Guha A, Kwon YK, Carroll RS, Black PM, Stiles CD. Shamah SM, et al. Among authors: guha a. Cancer Res. 1997 Sep 15;57(18):4141-7. Cancer Res. 1997. PMID: 9307305
Phosphorylated tyrosine 751 is a recognition site for phosphatidylinositol 3'-kinase, a cytoplasmic effector of PDGF-induced mitogenesis, chemotaxis, and membrane ruffling. ...These findings are consistent with a role for activated PDGF receptors in the proli …
Phosphorylated tyrosine 751 is a recognition site for phosphatidylinositol 3'-kinase, a cytoplasmic effector of PDGF-induced m …
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.
Shamah SM, Stiles CD, Guha A. Shamah SM, et al. Among authors: guha a. Mol Cell Biol. 1993 Dec;13(12):7203-12. doi: 10.1128/mcb.13.12.7203. Mol Cell Biol. 1993. PMID: 8246942 Free PMC article.
Most astrocytomas express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could close an autocrine loop. ...Here we show that dominant-negative mutants of the PDGF ligand break the autocrine loop and revert the phenotype of BALB/c 3T3 cells t …
Most astrocytomas express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could close an autocrine loo …
Platelet-derived growth factor: a general review with emphasis on astrocytomas.
Guha A. Guha A. Pediatr Neurosurg. 1991-1992;17(1):14-20. doi: 10.1159/000120559. Pediatr Neurosurg. 1991. PMID: 1667361 Review.
Growth factors acting in a paracrine or autocrine fashion are important in the development of normal cellular structures, and possibly in the development of neoplasia. ...This paper reviews the story of PDGF in a much oversimplified, however, hopefully understandabl …
Growth factors acting in a paracrine or autocrine fashion are important in the development of normal cellular structures, and possibl …
Isotype-specific Ras.GTP-levels predict the efficacy of farnesyl transferase inhibitors against human astrocytomas regardless of Ras mutational status.
Feldkamp MM, Lau N, Roncari L, Guha A. Feldkamp MM, et al. Among authors: guha a. Cancer Res. 2001 Jun 1;61(11):4425-31. Cancer Res. 2001. PMID: 11389071
SCH66336 is a potent FTI presently undergoing clinical trials in patients with solid tumors. We evaluated the efficacy of SCH66336 against a panel of eight human astrocytoma cell lines and three human astrocytoma explant xenograft models in NOD-SCID mice. ...Drug ef …
SCH66336 is a potent FTI presently undergoing clinical trials in patients with solid tumors. We evaluated the efficacy of SCH66336 ag …
Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.
Guha A, Dashner K, Black PM, Wagner JA, Stiles CD. Guha A, et al. Int J Cancer. 1995 Jan 17;60(2):168-73. doi: 10.1002/ijc.2910600206. Int J Cancer. 1995. PMID: 7829210
Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. ...Malignant astrocytomas, and to a lesser extent low-grade astrocytomas, …
Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (P …
Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome.
Guha A, Glowacka D, Carroll R, Dashner K, Black PM, Stiles CD. Guha A, et al. J Neurol Neurosurg Psychiatry. 1995 Jun;58(6):711-4. doi: 10.1136/jnnp.58.6.711. J Neurol Neurosurg Psychiatry. 1995. PMID: 7608673 Free PMC article.
Expression of platelet derived growth factor (PDGF) and PDGF-receptor mRNA was examined from a glioblastoma taken from a patient with Li-Fraumeni syndrome. Northern blot analysis and in situ hybridisation showed very high concentrations of both PDGF-A and PDG …
Expression of platelet derived growth factor (PDGF) and PDGF-receptor mRNA was examined from a glioblastoma taken from a patie …
Screening for loss of heterozygosity and microsatellite instability in oligodendrogliomas.
Zhu JJ, Santarius T, Wu X, Tsong J, Guha A, Wu JK, Hudson TJ, Black PM. Zhu JJ, et al. Among authors: guha a. Genes Chromosomes Cancer. 1998 Mar;21(3):207-16. doi: 10.1002/(sici)1098-2264(199803)21:3<207::aid-gcc4>3.3.co;2-7. Genes Chromosomes Cancer. 1998. PMID: 9523195
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Guha A, Vasconcelos M, Cai Y, Yoneda M, Hinds A, Qian J, Li G, Dickel L, Johnson JE, Kimura S, Guo J, McMahon J, McMahon AP, Cardoso WV. Guha A, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12592-7. doi: 10.1073/pnas.1204710109. Epub 2012 Jul 13. Proc Natl Acad Sci U S A. 2012. PMID: 22797898 Free PMC article.
Here we identify expression of the secretoglobin Scgb3a2 and Notch activation as early events in a program of secretory cell fate determination in developing murine airways. ...Together, our findings suggest a role for Notch in the induction of a Clara cell-s …
Here we identify expression of the secretoglobin Scgb3a2 and Notch activation as early events in a program of secretory cell fate det …
Uroplakin 3a(+) Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.
Guha A, Deshpande A, Jain A, Sebastiani P, Cardoso WV. Guha A, et al. Cell Rep. 2017 Apr 11;19(2):246-254. doi: 10.1016/j.celrep.2017.03.051. Cell Rep. 2017. PMID: 28402849
A recent screen for CC markers identified rare Uroplakin3a (Upk3a)-expressing cells(U-CCs) with a v-CC-like distribution. Here, we employ lineage analysis in the uninjured and chemically injured lungs to investigate therole of U-CCs as epithelial progenitors. ...U-C
A recent screen for CC markers identified rare Uroplakin3a (Upk3a)-expressing cells(U-CCs) with a v-CC-like distribution. Here
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