Guida WC - Search Results

1

In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery.

Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH. Campbell CO, et al. Among authors: guida wc. Chem Biol Drug Des. 2014 Aug;84(2):158-68. doi: 10.1111/cbdd.12315. Epub 2014 May 12. Chem Biol Drug Des. 2014. PMID: 24605883 Free PMC article.

2

Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics.

Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Anderson L, et al. Among authors: guida wc. J Org Chem. 2010 Jun 18;75(12):4288-91. doi: 10.1021/jo100272d. J Org Chem. 2010. PMID: 20469918 Free PMC article.

3

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors.

Lawrence HR, Kazi A, Luo Y, Kendig R, Ge Y, Jain S, Daniel K, Santiago D, Guida WC, Sebti SM. Lawrence HR, et al. Among authors: guida wc. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. doi: 10.1016/j.bmc.2010.06.038. Epub 2010 Jun 18. Bioorg Med Chem. 2010. PMID: 20621484 Free PMC article.

4

Virtual target screening: validation using kinase inhibitors.

Santiago DN, Pevzner Y, Durand AA, Tran M, Scheerer RR, Daniel K, Sung SS, Woodcock HL, Guida WC, Brooks WH. Santiago DN, et al. Among authors: guida wc. J Chem Inf Model. 2012 Aug 27;52(8):2192-203. doi: 10.1021/ci300073m. Epub 2012 Jul 23. J Chem Inf Model. 2012. PMID: 22747098 Free PMC article.

5

Production of recombinant 1-deoxy-d-xylulose-5-phosphate synthase from Plasmodium vivax in Escherichia coli.

Handa S, Ramamoorthy D, Spradling TJ, Guida WC, Adams JH, Bendinskas KG, Merkler DJ. Handa S, et al. Among authors: guida wc. FEBS Open Bio. 2013 Jan 28;3:124-9. doi: 10.1016/j.fob.2013.01.007. Print 2013. FEBS Open Bio. 2013. PMID: 23772383 Free PMC article.

6

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.

Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, Kyle DE, Manetsch R. Cross RM, et al. Among authors: guida wc. J Med Chem. 2014 Nov 13;57(21):8860-79. doi: 10.1021/jm500942v. Epub 2014 Oct 22. J Med Chem. 2014. PMID: 25148516 Free PMC article.

7

Bioactivity improvement via display of the hydrophobic core of HYD1 in a cyclic β-hairpin-like scaffold, MTI-101.

Jain P, Badger DB, Liang Y, Gebhard AW, Santiago D, Murray P, Kaulagari SR, Gauthier TJ, Nair R, Kumar M, Guida WC, Hazlehurst LA, McLaughlin ML. Jain P, et al. Among authors: guida wc. Pept Sci (Hoboken). 2021 May;113(3):e24199. doi: 10.1002/pep2.24199. Epub 2020 Oct 9. Pept Sci (Hoboken). 2021. PMID: 35859761 Free PMC article.

8

Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

Chen L, Sung SS, Yip ML, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Chen L, et al. Among authors: guida wc. Mol Pharmacol. 2006 Aug;70(2):562-70. doi: 10.1124/mol.106.025536. Epub 2006 May 22. Mol Pharmacol. 2006. PMID: 16717135

9

In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase.

Brooks WH, McCloskey DE, Daniel KG, Ealick SE, Secrist JA 3rd, Waud WR, Pegg AE, Guida WC. Brooks WH, et al. Among authors: guida wc. J Chem Inf Model. 2007 Sep-Oct;47(5):1897-905. doi: 10.1021/ci700005t. Epub 2007 Aug 4. J Chem Inf Model. 2007. PMID: 17676832

10

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds.

Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ. Lawrence HR, et al. Among authors: guida wc. J Med Chem. 2008 Aug 28;51(16):4948-56. doi: 10.1021/jm8002526. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680359 Free PMC article.

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