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gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.
Massotti M, Schlichting JL, Antonacci MD, Giusti P, Memo M, Costa E, Guidotti A. Massotti M, et al. J Pharmacol Exp Ther. 1991 Mar;256(3):1154-60. J Pharmacol Exp Ther. 1991. PMID: 1848629
The properties of [3H]clonazepam, [3H]diazepam and [3H]zolpidem (N,N,6[trimethyl-2-(4-methyl-phenyl)imidazo[1,2-a]pyridine-3-acetamide hemitratrate) binding to synaptic membranes of cerebellum, cortex, olfactory bulb, striatum and spinal cord of rat were compared to the bi …
The properties of [3H]clonazepam, [3H]diazepam and [3H]zolpidem (N,N,6[trimethyl-2-(4-methyl-phenyl)imidazo[1,2-a]pyridine-3-acetamid …
Cellular and subcellular localization of an octadecaneuropeptide derived from diazepam binding inhibitor: immunohistochemical studies in the rat brain.
Alho H, Bovolin P, Jenkins D, Guidotti A, Costa E. Alho H, et al. J Chem Neuroanat. 1989 Nov-Dec;2(6):301-18. J Chem Neuroanat. 1989. PMID: 2482048
ODN-LI includes a newly discovered family of rat brain neuropeptides that are processing products of a common endogenous neuropeptide precursor, diazepam binding inhibitor (DBI). ...The anti-ODN antiserum used in this study does not cross-react with rat DBI, and thu …
ODN-LI includes a newly discovered family of rat brain neuropeptides that are processing products of a common endogenous neuro …
Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites.
Antkiewicz-Michaluk L, Mukhin AG, Guidotti A, Krueger KE. Antkiewicz-Michaluk L, et al. J Biol Chem. 1988 Nov 25;263(33):17317-21. J Biol Chem. 1988. PMID: 2846560
Purified preparations of PKBS exhibited a single band with a Mr of approximately 17,000 when analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by silver-staining or autoradiographic detection. ...These results demonstrate that a p …
Purified preparations of PKBS exhibited a single band with a Mr of approximately 17,000 when analyzed by sodium dodecyl sulfat …
A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain.
Guarneri P, Berkovich A, Guidotti A, Costa E. Guarneri P, et al. Neuropharmacology. 1990 May;29(5):419-28. doi: 10.1016/0028-3908(90)90162-k. Neuropharmacology. 1990. PMID: 2356001
Diazepam binding inhibitor (DBI) is a neuropeptide of 11 kDa molecular size and is unevenly distributed in human and rat brain. ...On the basis of the immunological properties, a tentative amino acid sequence was deduced....
Diazepam binding inhibitor (DBI) is a neuropeptide of 11 kDa molecular size and is unevenly distributed in human and rat brain. ...On …
A search for a new anticonvulsant and anxiolytic benzodiazepine devoid of side effects and tolerance liability.
Costa E, Auta J, Caruncho H, Guidotti A, Impagnatiello F, Pesold C, Thompson DM. Costa E, et al. Adv Biochem Psychopharmacol. 1995;48:75-92. Adv Biochem Psychopharmacol. 1995. PMID: 7653327 Review. No abstract available.
Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site.
Slobodyansky E, Guidotti A, Wambebe C, Berkovich A, Costa E. Slobodyansky E, et al. J Neurochem. 1989 Oct;53(4):1276-84. doi: 10.1111/j.1471-4159.1989.tb07425.x. J Neurochem. 1989. PMID: 2769267
This report describes the purification and characterization from rat brain of triakontatetraneuropeptide (TTN, DBI 17-50), a major biologically active processing product of diazepam binding inhibitor (DBI). ...These data suggest that TTN, a natural DBI processing pr …
This report describes the purification and characterization from rat brain of triakontatetraneuropeptide (TTN, DBI 17-50), a major bi …
Intrinsic gamma aminobutyric acid receptors modulate the release of catecholamine from canine adrenal gland in situ.
Kataoka Y, Fujimoto M, Alho H, Guidotti A, Geffard M, Kelly GD, Hanbauer I. Kataoka Y, et al. J Pharmacol Exp Ther. 1986 Nov;239(2):584-90. J Pharmacol Exp Ther. 1986. PMID: 2877086
A dense network of fibers was visualized at the boundary between medullary and cortical cells, and, in the medullary tissue, GABA-containing fibers surrounded chromaffin cells. ...Baclofen (0.094 mmol/2 ml min-1), a GABAB receptor agonist, failed to alter the catech
A dense network of fibers was visualized at the boundary between medullary and cortical cells, and, in the medullary tissue, GABA-con
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
Fujimoto M, Kataoka Y, Guidotti A, Hanbauer I. Fujimoto M, et al. J Pharmacol Exp Ther. 1987 Oct;243(1):195-9. J Pharmacol Exp Ther. 1987. PMID: 2822897
A stoichiometric relationship exists between the release of both substances; 1 nmol/ml of plasma of catecholamines was coreleased with 2 pmol/ml of plasma of ME-like peptides. ...A similar profile for the release of ME-like peptides was obtained when electrical stim
A stoichiometric relationship exists between the release of both substances; 1 nmol/ml of plasma of catecholamines was coreleased wit
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