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Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.
Guillermet-Guibert J, Smith LB, Halet G, Whitehead MA, Pearce W, Rebourcet D, León K, Crépieux P, Nock G, Strömstedt M, Enerback M, Chelala C, Graupera M, Carroll J, Cosulich S, Saunders PT, Huhtaniemi I, Vanhaesebroeck B. Guillermet-Guibert J, et al. PLoS Genet. 2015 Jul 1;11(7):e1005304. doi: 10.1371/journal.pgen.1005304. eCollection 2015 Jul. PLoS Genet. 2015. PMID: 26132308 Free PMC article.
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. Guillermet-Guibert J, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. doi: 10.1073/pnas.0707761105. Epub 2008 Jun 10. Proc Natl Acad Sci U S A. 2008. PMID: 18544649 Free PMC article.
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.
Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S, Chandarana K, Bell JD, Barsh GS, Smith AJ, Batterham RL, Ashford ML, Vanhaesebroeck B, Withers DJ. Al-Qassab H, et al. Cell Metab. 2009 Nov;10(5):343-54. doi: 10.1016/j.cmet.2009.09.008. Cell Metab. 2009. PMID: 19883613 Free PMC article.
The emerging mechanisms of isoform-specific PI3K signalling.
Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. Vanhaesebroeck B, et al. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9. Nat Rev Mol Cell Biol. 2010. PMID: 20379207 Review.
46 results