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Page 1
(-)-Epicatechin Is a Biased Ligand of Apelin Receptor.
Portilla-Martínez A, Ortiz-Flores MÁ, Meaney E, Villarreal F, Nájera N, Ceballos G. Portilla-Martínez A, et al. Among authors: ceballos g. Int J Mol Sci. 2022 Aug 11;23(16):8962. doi: 10.3390/ijms23168962. Int J Mol Sci. 2022. PMID: 36012227 Free PMC article.
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
(-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids and is widely distributed in the plant kingdom. ...
Beneficial Effects of Flavonoids on Skeletal Muscle Health: A Systematic Review and Meta-Analysis.
Munguía L, Ortiz M, González C, Portilla A, Meaney E, Villarreal F, Nájera N, Ceballos G. Munguía L, et al. Among authors: ceballos g. J Med Food. 2022 May;25(5):465-486. doi: 10.1089/jmf.2021.0054. Epub 2022 Apr 8. J Med Food. 2022. PMID: 35394826
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "catechins" OR "epicatechin" OR "(-)-epicatechin" AND "skeletal muscle." The studies included in this review were preclinical stu …
The following search terms were used: "flavonoids" OR "flavanols" OR "flavones" OR "anthocyanidins" OR "flavanones" OR "flavan-3-ols" OR "ca …
Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data.
Hidalgo I, Ortiz-Flores M, Villarreal F, Fonseca-Coronado S, Ceballos G, Meaney E, Nájera N. Hidalgo I, et al. Among authors: ceballos g. J Basic Clin Physiol Pharmacol. 2022 Feb 4;33(6):703-714. doi: 10.1515/jbcpp-2021-0285. eCollection 2022 Nov 1. J Basic Clin Physiol Pharmacol. 2022. PMID: 35119232 Review.
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main catechin in green tea, which has shown in various studies its potential effect preventing and treating NAFLD since it has shown anti …
In this article, the beneficial effects of epigallocatechin-3-gallate (EGCG) and (-)-epicatechin (EC) are discussed. EGCG is the main …
Perturbations in skeletal muscle sarcomere structure in patients with heart failure and type 2 diabetes: restorative effects of (-)-epicatechin-rich cocoa.
Taub PR, Ramirez-Sanchez I, Ciaraldi TP, Gonzalez-Basurto S, Coral-Vazquez R, Perkins G, Hogan M, Maisel AS, Henry RR, Ceballos G, Villarreal F. Taub PR, et al. Among authors: ceballos g. Clin Sci (Lond). 2013 Oct;125(8):383-9. doi: 10.1042/CS20130023. Clin Sci (Lond). 2013. PMID: 23642227
We have demonstrated recently that (-)-ERC (epicatechin-rich cocoa) improves SkM mitochondrial structure [Taub, Ramirez-Sanchez, Ciaraldi, Perkins, Murphy, Naviaux, Hogan, Ceballos, Maisel, Henry et al. (2012) Clin. ...These initial results warrant further rigorous investi …
We have demonstrated recently that (-)-ERC (epicatechin-rich cocoa) improves SkM mitochondrial structure [Taub, Ramirez-Sanchez, Ciar …
Arginase inhibition by (-)-Epicatechin reverses endothelial cell aging.
Garate-Carrillo A, Navarrete-Yañez V, Ortiz-Vilchis P, Guevara G, Castillo C, Mendoza-Lorenzo P, Ceballos G, Ortiz-Flores M, Najera N, Bustamante-Pozo MM, Rubio-Gayosso I, Villarreal F, Ramirez-Sanchez I. Garate-Carrillo A, et al. Among authors: ceballos g. Eur J Pharmacol. 2020 Oct 15;885:173442. doi: 10.1016/j.ejphar.2020.173442. Epub 2020 Aug 11. Eur J Pharmacol. 2020. PMID: 32795514 Free PMC article.
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in silico modeling we demonstrate that Epi interacts with Ar similarly to its inhibitor Norvaline (Norv). ...
The inhibition of Ar activity can reverse EnD and (-)-epicatechin (Epi) inhibits myocardial Ar activity. In this study, through in si …
11-beta-hydroxysterols as possible endogenous stimulators of mitochondrial biogenesis as inferred from epicatechin molecular mimicry.
Dugar S, Villarreal F, Hollinger FH, Mahajan D, Ramirez-Sanchez I, Moreno-Ulloa A, Ceballos G, Schreiner G. Dugar S, et al. Among authors: ceballos g. Pharmacol Res. 2020 Jan;151:104540. doi: 10.1016/j.phrs.2019.104540. Epub 2019 Nov 10. Pharmacol Res. 2020. PMID: 31722227
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin has been reported to activate cells surface receptors leading to the stimulation of MB in endothelial and skeletal muscle cells translating i …
The molecular size of the cacao flavanols (epicatechin and catechin) highly resembles that of sterols and epicatechin h …
Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.
Gutierrez-Salmean G, Ciaraldi TP, Nogueira L, Barboza J, Taub PR, Hogan MC, Henry RR, Meaney E, Villarreal F, Ceballos G, Ramirez-Sanchez I. Gutierrez-Salmean G, et al. Among authors: ceballos g. J Nutr Biochem. 2014 Jan;25(1):91-4. doi: 10.1016/j.jnutbio.2013.09.007. Epub 2013 Oct 18. J Nutr Biochem. 2014. PMID: 24314870 Free PMC article.
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in mice, and Epi-rich cocoa improves skeletal muscle structure in heart failure patients. (-)-Epicatechin may thus hold promise as trea …
Flavonoids are known for their healthy effects and limited toxicity. The flavanol (-)-epicatechin (Epi) enhances exercise capacity in …
Enhancement of Statin Effects on Lipid Lowering and Reduction of Cardiovascular Risk Score by (-)-Epicatechin in Proof-of-Concept Pilot Study.
Ormiston CK, Pazargadi A, Rosander A, Ceballos G, Villarreal F, Taub PR. Ormiston CK, et al. Among authors: ceballos g. Clin Transl Sci. 2025 May;18(5):e70236. doi: 10.1111/cts.70236. Clin Transl Sci. 2025. PMID: 40387782 Free PMC article. Clinical Trial.
There remains an unmet need for strategies that improve statin tolerance and synergize their effect on atherogenic lipids. (-)-Epicatechin (Epi) is a natural flavonoid that can improve lipid biomarkers and mitochondrial function. ...
There remains an unmet need for strategies that improve statin tolerance and synergize their effect on atherogenic lipids. (-)-Epicatechi …
Improving Cardiovascular Risk in Postmenopausal Women with an (-)-Epicatechin-Based Nutraceutical: A Randomly Assigned, Double-Blind vs. Placebo, Proof-of-Concept Trial.
Nájera N, Ortíz-Flores M, Pérez-Durán J, Reyes-Muñoz E, Romo-Yañez J, Ortiz-Luna G, Villarreal F, Meaney E, Ceballos G, Montoya-Estrada A. Nájera N, et al. Among authors: ceballos g. J Clin Med. 2023 Dec 29;13(1):195. doi: 10.3390/jcm13010195. J Clin Med. 2023. PMID: 38202201 Free PMC article.
The objective was to evaluate the changes in lipoprotein subfractions induced by three months of treatment with an epicatechin-enriched cacao supplement. METHODS: A double-blind, placebo-controlled proof-of-concept study was developed to evaluate the effects of 3 months of …
The objective was to evaluate the changes in lipoprotein subfractions induced by three months of treatment with an epicatechin-enrich …
(-)-Epicatechin Inhibits Metastatic-Associated Proliferation, Migration, and Invasion of Murine Breast Cancer Cells In Vitro.
Pérez-Durán J, Luna A, Portilla A, Martínez P, Ceballos G, Ortíz-Flores MÁ, Solis-Paredes JM, Nájera N. Pérez-Durán J, et al. Among authors: ceballos g. Molecules. 2023 Aug 24;28(17):6229. doi: 10.3390/molecules28176229. Molecules. 2023. PMID: 37687058 Free PMC article.
Current chemotherapy uses non-specific cytotoxic drugs, which inhibit tumor growth but cause significant adverse effects. (-)-Epicatechin (EC) is part of a large family of biomolecules called flavonoids. It is widely distributed in the plant kingdom; it can be found in gre …
Current chemotherapy uses non-specific cytotoxic drugs, which inhibit tumor growth but cause significant adverse effects. (-)-Epicatechin …
57 results