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Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes.
Burban A, Sharanek A, Guguen-Guillouzo C, Guillouzo A. Burban A, et al. Among authors: guillouzo a. Free Radic Biol Med. 2018 Feb 1;115:166-178. doi: 10.1016/j.freeradbiomed.2017.11.017. Epub 2017 Dec 2. Free Radic Biol Med. 2018. PMID: 29191461
Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes.
Sharanek A, Burban A, Humbert L, Bachour-El Azzi P, Felix-Gomes N, Rainteau D, Guillouzo A. Sharanek A, et al. Toxicol Sci. 2015 Oct;147(2):573-87. doi: 10.1093/toxsci/kfv155. Epub 2015 Jul 20. Toxicol Sci. 2015. PMID: 26198044
We have evaluated the capacity of the human HepaRG cell line to synthesize, conjugate, and secrete BAs, and analyzed changes in BA content and profile after cyclosporine A (CsA) treatment. ...Noteworthy, HepaRG cells incubated in a 2% serum-supplemented medium showe …
We have evaluated the capacity of the human HepaRG cell line to synthesize, conjugate, and secrete BAs, and analyzed changes in BA content a …
Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project.
Mueller SO, Guillouzo A, Hewitt PG, Richert L. Mueller SO, et al. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):19-26. doi: 10.1016/j.tiv.2015.04.014. Epub 2015 May 4. Toxicol In Vitro. 2015. PMID: 25952325 Review.
One major focus was the prediction of hepatotoxicity as liver remains one of the major organ leading to failure in drug development, drug withdrawal and has a poor predictivity from animal experiments. ...Further compounds have to be analyzed in a broader concentrat …
One major focus was the prediction of hepatotoxicity as liver remains one of the major organ leading to failure in drug development, drug wi …
Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems.
Truisi GL, Consiglio ED, Parmentier C, Savary CC, Pomponio G, Bois F, Lauer B, Jossé R, Hewitt PG, Mueller SO, Richert L, Guillouzo A, Testai E. Truisi GL, et al. Toxicol Lett. 2015 Mar 4;233(2):172-86. doi: 10.1016/j.toxlet.2015.01.006. Epub 2015 Jan 8. Toxicol Lett. 2015. PMID: 25578229
A cross-model comparison was carried out at 100μM, roughly corresponding to the human therapeutic plasma concentration. Our results showed that IBU uptake was rapid and a dynamic equilibrium was reached within 1 or 2 days. ...In PHH, a low CYP2C9 activity, th
A cross-model comparison was carried out at 100μM, roughly corresponding to the human therapeutic plasma concentration. Our results s
Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells.
Josse R, Sharanek A, Savary CC, Guillouzo A. Josse R, et al. Chem Biol Interact. 2014 Feb 25;209:68-76. doi: 10.1016/j.cbi.2013.12.002. Epub 2013 Dec 12. Chem Biol Interact. 2014. PMID: 24333466
Isomalathion is a major impurity of technical grade malathion, one of the most abundantly applied insecticides; however little is known about its hepatotoxicity. ...Isomalathion reduced cell viability starting at a 100 μM concentration after a 24h exposure. I …
Isomalathion is a major impurity of technical grade malathion, one of the most abundantly applied insecticides; however little is kno …
Interindividual variability in gene expression profiles in human hepatocytes and comparison with HepaRG cells.
Rogue A, Lambert C, Spire C, Claude N, Guillouzo A. Rogue A, et al. Drug Metab Dispos. 2012 Jan;40(1):151-8. doi: 10.1124/dmd.111.042028. Epub 2011 Oct 12. Drug Metab Dispos. 2012. PMID: 21994436
HepaRG cells expressed from 81 to 92% of the genes active in human hepatocytes and, in addition, a specific gene subset mainly related to their transformed status, some chromosomal abnormalities, and the presence of primitive biliary epithelial cells. Of interest, a
HepaRG cells expressed from 81 to 92% of the genes active in human hepatocytes and, in addition, a specific gene subset mainly relate …
Activation of C-Jun N-terminal kinase is required for glutathione transferase A4 induction during oxidative stress, not during cell proliferation, in mouse hepatocytes.
Desmots F, Loyer P, Rissel M, Guillouzo A, Morel F. Desmots F, et al. FEBS Lett. 2005 Oct 24;579(25):5691-6. doi: 10.1016/j.febslet.2005.08.088. Epub 2005 Oct 4. FEBS Lett. 2005. PMID: 16223495
A second mGSTA4 induction occurred 2 days after cell seeding concomitantly to DNA replication and was prevented by treatment with mitogen-activated protein kinase (MEK) inhibitor U0126. ...
A second mGSTA4 induction occurred 2 days after cell seeding concomitantly to DNA replication and was prevented by treatment with mit
Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes.
Rogue A, Renaud MP, Claude N, Guillouzo A, Spire C. Rogue A, et al. Toxicol Appl Pharmacol. 2011 Jul 1;254(1):18-31. doi: 10.1016/j.taap.2011.04.005. Epub 2011 Apr 14. Toxicol Appl Pharmacol. 2011. PMID: 21515302
Although, hierarchical clustering revealed a gene expression profile characteristic of each PPAR agonist class, only a limited number of genes was specifically deregulated by glitazars. ...Taken altogether, these results support the conclusion that differential toxi …
Although, hierarchical clustering revealed a gene expression profile characteristic of each PPAR agonist class, only a limited …
Evolving concepts in liver tissue modeling and implications for in vitro toxicology.
Guillouzo A, Guguen-Guillouzo C. Guillouzo A, et al. Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1279-94. doi: 10.1517/17425255.4.10.1279. Expert Opin Drug Metab Toxicol. 2008. PMID: 18798698 Review.
For mimicking the liver, a major target of toxic chemicals, primary hepatocytes represent the most pertinent model. Their use is limited by interdonor functional variability and early phenotypic changes although their lifespan can be extended not only by culturing in a
For mimicking the liver, a major target of toxic chemicals, primary hepatocytes represent the most pertinent model. Their use is limi …
Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.
Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Petit E, et al. Toxicol In Vitro. 2008 Apr;22(3):632-42. doi: 10.1016/j.tiv.2007.12.004. Epub 2008 Jan 25. Toxicol In Vitro. 2008. PMID: 18222062
Despite these advantages, their therapeutic potential is limited by occasional adverse effects (myelotoxicity and hepatotoxicity) and by a relatively frequent lack of efficacy. ...The toxic effects appeared after 96 h of treatment while ATP depletion was observed after …
Despite these advantages, their therapeutic potential is limited by occasional adverse effects (myelotoxicity and hepatotoxicity) and by …
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