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Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity.
Guimarães MA, de Oliveira RN, de Almeida RL, Mafud AC, Sarkis ALV, Ganassin R, da Silva MP, Roquini DB, Veras LM, Sawada TCH, Ropke CD, Muehlmann LA, Joanitti GA, Kuckelhaus SAS, Allegretti SM, Mascarenhas YP, de Moraes J, Leite JRSA. Guimarães MA, et al. PLoS One. 2018 May 11;13(5):e0196667. doi: 10.1371/journal.pone.0196667. eCollection 2018. PLoS One. 2018. PMID: 29750792 Free PMC article.
Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni.
Guimarães MA, de Oliveira RN, Véras LM, Lima DF, Campelo YD, Campos SA, Kuckelhaus SA, Pinto PL, Eaton P, Mafud AC, Mascarenhas YP, Allegretti SM, de Moraes J, Lolić A, Verbić T, Leite JR. Guimarães MA, et al. PLoS Negl Trop Dis. 2015 Mar 27;9(3):e0003656. doi: 10.1371/journal.pntd.0003656. eCollection 2015 Mar. PLoS Negl Trop Dis. 2015. PMID: 25816129 Free PMC article.
Synergistic effects of in vitro combinations of piplartine, epiisopiloturine and praziquantel against Schistosoma mansoni.
Campelo YDM, Mafud AC, Véras LMC, Guimarães MA, Yamaguchi LF, Lima DF, Arcanjo DDR, Kato MJ, Mendonça RZ, Pinto PLS, Mascarenhas YP, Silva MPN, de Moraes J, Eaton P, de Souza de Almeida Leite JR. Campelo YDM, et al. Among authors: guimaraes ma. Biomed Pharmacother. 2017 Apr;88:488-499. doi: 10.1016/j.biopha.2016.12.057. Epub 2017 Jan 23. Biomed Pharmacother. 2017. PMID: 28126674
Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.
de Lima LI, Py-Daniel KR, Guimarães MA, Muehlmann LA, Mafud AC, Mascarenhas YP, Moraes J, de Souza de Almeida Leite JR, Jiang CS, Azevedo RB, Figueiró Longo JP. de Lima LI, et al. Among authors: guimaraes ma. Nanomedicine (Lond). 2018 Apr 1;13(7):689-702. doi: 10.2217/nnm-2017-0308. Epub 2018 Mar 22. Nanomedicine (Lond). 2018. PMID: 29564947
Effect of neem (Azadirachta indica A. Juss) leaf extract on resistant Staphylococcus aureus biofilm formation and Schistosoma mansoni worms.
Quelemes PV, Perfeito ML, Guimarães MA, dos Santos RC, Lima DF, Nascimento C, Silva MP, Soares MJ, Ropke CD, Eaton P, de Moraes J, Leite JR. Quelemes PV, et al. Among authors: guimaraes ma. J Ethnopharmacol. 2015 Dec 4;175:287-94. doi: 10.1016/j.jep.2015.09.026. Epub 2015 Sep 25. J Ethnopharmacol. 2015. PMID: 26408045 Free article.
Activity of epiisopiloturine against Schistosoma mansoni.
Veras LM, Guimaraes MA, Campelo YD, Vieira MM, Nascimento C, Lima DF, Vasconcelos L, Nakano E, Kuckelhaus SS, Batista MC, Leite JR, Moraes J. Veras LM, et al. Among authors: guimaraes ma. Curr Med Chem. 2012;19(13):2051-8. doi: 10.2174/092986712800167347. Curr Med Chem. 2012. PMID: 22420337
Industrial Scale Isolation, Structural and Spectroscopic Characterization of Epiisopiloturine from Pilocarpus microphyllus Stapf Leaves: A Promising Alkaloid against Schistosomiasis.
Véras LM, Cunha VR, Lima FC, Guimarães MA, Vieira MM, Campelo YD, Sakai VY, Lima DF, Carvalho PS Jr, Ellena JA, Silva PR, Vasconcelos LC, Godejohann M, Petrilli HM, Constantino VR, Mascarenhas YP, de Souza de Almeida Leite JR. Véras LM, et al. Among authors: guimaraes ma. PLoS One. 2013 Jun 26;8(6):e66702. doi: 10.1371/journal.pone.0066702. Print 2013. PLoS One. 2013. PMID: 23840522 Free PMC article.
Silver nanoparticle stabilized by hydrolyzed collagen and natural polymers: Synthesis, characterization and antibacterial-antifungal evaluation.
Nogueira SS, de Araujo-Nobre AR, Mafud AC, Guimarães MA, Alves MMM, Plácido A, Carvalho FAA, Arcanjo DDR, Mascarenhas Y, Costa FG, Albuquerque P, Eaton P, de Souza de Almeida Leite JR, da Silva DA, Cardoso VS. Nogueira SS, et al. Among authors: guimaraes ma. Int J Biol Macromol. 2019 Aug 15;135:808-814. doi: 10.1016/j.ijbiomac.2019.05.214. Epub 2019 May 31. Int J Biol Macromol. 2019. PMID: 31158421
130 results