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Evidence that morphine tolerance may be regulated by endothelin in the neonatal rat.
Puppala BL, Matwyshyn G, Bhalla S, Gulati A. Puppala BL, et al. Biol Neonate. 2004;86(2):138-44. doi: 10.1159/000079272. Epub 2004 Jun 22. Biol Neonate. 2004. PMID: 15218283
Management of tolerance and withdrawal symptoms in neonates remains a major challenge. OBJECTIVES: The present study investigates the involvement of a central endothelin (ET) mechanism in the development of tolerance to morphine in neonatal rats. ...The ETB receptor …
Management of tolerance and withdrawal symptoms in neonates remains a major challenge. OBJECTIVES: The present study investigates the …
Selective Endothelin-B Receptor Stimulation Increases Vascular Endothelial Growth Factor in the Rat Brain during Postnatal Development.
Leonard MG, Prazad P, Puppala B, Gulati A. Leonard MG, et al. Drug Res (Stuttg). 2015 Nov;65(11):607-13. doi: 10.1055/s-0034-1398688. Epub 2015 Mar 25. Drug Res (Stuttg). 2015. PMID: 25806822
In order to determine the effect of ET(B) receptor stimulation, a separate group of pups were administered saline or ET(B) receptor agonist, IRL-1620, on day 21, and their brains were analyzed on day 28. ...Results indicate that ET(B) receptors appear to play a role …
In order to determine the effect of ET(B) receptor stimulation, a separate group of pups were administered saline or ET(B) receptor a …
Endothelin mechanisms in altered thyroid states in the rat.
Rebello S, Thompson EB, Gulati A. Rebello S, et al. Eur J Pharmacol. 1993 Jun 11;237(1):9-16. doi: 10.1016/0014-2999(93)90086-w. Eur J Pharmacol. 1993. PMID: 8359210
Binding studies showed that [125I]ET-1 bound to a single, high affinity binding site in the cerebral cortex, hypothalamus and pituitary. ...The pituitary of thyroxine-treated rats showed a decrease in the binding (34.3% decrease in the density) of [125I]ET-1 as comp …
Binding studies showed that [125I]ET-1 bound to a single, high affinity binding site in the cerebral cortex, hypothalamus and pituita …
Renal actions of endothelin-1 in newborn piglets: dose-effect relation and the effects of receptor antagonist (BQ-123) and cyclooxygenase inhibitor (indomethacin).
Bhat R, John E, Chari G, Shankararao R, Fornell L, Gulati A, Vidyasagar D. Bhat R, et al. J Lab Clin Med. 1995 Nov;126(5):458-69. J Lab Clin Med. 1995. PMID: 7595031
In addition, the effects of pretreatment with a receptor antagonist (BQ-123) and with a cyclooxygenase inhibitor (indomethacin) were studied in 12 separate piglets. ET-1 produced a dose- and level-dependent decrease in CI (60%), RBF (50% to 75%), GFR (66% to …
In addition, the effects of pretreatment with a receptor antagonist (BQ-123) and with a cyclooxygenase inhibitor (indomethacin …
Spinal cord thyrotropin releasing hormone receptors of morphine tolerant-dependent and abstinent rats.
Rahmani NH, Gulati A, Bhargava HN. Rahmani NH, et al. Peptides. 1990 Jul-Aug;11(4):693-5. doi: 10.1016/0196-9781(90)90182-5. Peptides. 1990. PMID: 2172939
Male Sprague-Dawley rats were implanted with either 6 placebo or 6 morphine pellets (each containing 75-mg morphine base) during a 7-day period. ...In placebo-pellet-implanted rats, 3H-MeTRH bound to the spinal cord membranes at a single high affinity binding site w …
Male Sprague-Dawley rats were implanted with either 6 placebo or 6 morphine pellets (each containing 75-mg morphine base) during a 7- …
Ontogeny of endothelin and its receptors in rat brain.
Gulati A, Rebello S, Chari G, Bhat R. Gulati A, et al. Life Sci. 1992;51(22):1715-24. doi: 10.1016/0024-3205(92)90300-e. Life Sci. 1992. PMID: 1435080
It is concluded that ET and its receptors are developmentally regulated and there is a possibility that endogenous ET is involved in the regulation of ET receptor density....
It is concluded that ET and its receptors are developmentally regulated and there is a possibility that endogenous ET is involved in …
Cardiovascular effects of centrally administered endothelin-1 in rats.
Gulati A, Rebello S, Roy S, Saxena PR. Gulati A, et al. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S244-6. J Cardiovasc Pharmacol. 1995. PMID: 8587377
However, the highest dose (45 ng) produced a transient rise followed by a sustained fall in BP. The CO and SV decreased significantly, whereas HR and TPR were not affected. ...Centrally administered IRL 1620, a specific ETB receptor agonist, did not produce a …
However, the highest dose (45 ng) produced a transient rise followed by a sustained fall in BP. The CO and SV decreased signif …
Repeated administration of ET(B) receptor agonist, IRL-1620, produces tachyphylaxis only to its hypotensive effect.
Leonard MG, Gulati A. Leonard MG, et al. Pharmacol Res. 2009 Nov;60(5):402-10. doi: 10.1016/j.phrs.2009.07.015. Epub 2009 Aug 8. Pharmacol Res. 2009. PMID: 19666119
IRL-1620, a highly selective ET(B) receptor agonist, is presently in a phase I clinical trial (NCT00613691) in the United States for patients with recurrent or progressive carcinoma. ...Repeated administration of a low dose (1.6microg/kg, i.v.) of IRL-1620 pr …
IRL-1620, a highly selective ET(B) receptor agonist, is presently in a phase I clinical trial (NCT00613691) in the United Stat …
Endothelin Receptors, Mitochondria and Neurogenesis in Cerebral Ischemia.
Gulati A. Gulati A. Curr Neuropharmacol. 2016;14(6):619-26. doi: 10.2174/1570159x14666160119094959. Curr Neuropharmacol. 2016. PMID: 26786146 Free PMC article. Review.
Study of adrenergic, imidazoline, and endothelin receptors in clonidine-, morphine-, and oxycodone-induced changes in rat body temperature.
Bhalla S, Andurkar SV, Gulati A. Bhalla S, et al. Pharmacology. 2011;87(3-4):169-79. doi: 10.1159/000324537. Epub 2011 Mar 8. Pharmacology. 2011. PMID: 21389745
OBJECTIVES: The potentiation of morphine or oxycodone analgesia by endothelin-A (ET(A)) receptor antagonists and imidazoline/α(2)-adrenergic agonists is well documented. ...Yohimbine, idazoxan, and BMS182874 were used to determine the involvement of α(2)-adrenergic, …
OBJECTIVES: The potentiation of morphine or oxycodone analgesia by endothelin-A (ET(A)) receptor antagonists and imidazoline/α …
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