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Morphine tolerance does not develop in mice treated with endothelin-A receptor antagonists.
Bhalla S, Matwyshyn G, Gulati A. Bhalla S, et al. Brain Res. 2005 Dec 7;1064(1-2):126-35. doi: 10.1016/j.brainres.2005.09.054. Epub 2005 Nov 14. Brain Res. 2005. PMID: 16289404
In the present study, we investigated the effect of ET(A) receptor antagonists, BQ123 and BMS182874, on morphine antinociception and tolerance in mice. ...Treatment with a single dose of BQ123 (3 microg, i.c.v.) reversed tolerance to morphine antinociception in morp …
In the present study, we investigated the effect of ET(A) receptor antagonists, BQ123 and BMS182874, on morphine antinociception and …
Down-regulation of central receptors for thyrotropin-releasing hormone in kappa opiate agonist-induced abstinence in the rat.
Bhargava HN, Gulati A, Rahmani NH. Bhargava HN, et al. Neuropharmacology. 1992 Feb;31(2):137-41. doi: 10.1016/0028-3908(92)90023-i. Neuropharmacology. 1992. PMID: 1313157
The effect of U-50,488H, a selective kappa opiate agonist, on tolerance-dependence and abstinence on the TRH receptors of the spinal cord and discrete regions of the brain of male Sprague-Dawley rats was determined. ...The above procedure has been previously shown to produ …
The effect of U-50,488H, a selective kappa opiate agonist, on tolerance-dependence and abstinence on the TRH receptors of the spinal …
Characteristics of endothelin receptors in the central nervous system of spontaneously hypertensive rats.
Gulati A, Rebello S. Gulati A, et al. Neuropharmacology. 1992 Mar;31(3):243-50. doi: 10.1016/0028-3908(92)90174-n. Neuropharmacology. 1992. PMID: 1321357
The concentration-dependent inhibition of binding of [125I]ET-1 by unlabeled ET-1, in spinal cord membranes showed an IC50 value of 2.66 +/- 0.59 nM and a Ki value of 2.35 +/- 0.52 nM in WKY rats and an IC50 value of 2.82 +/- 0.76 nM and a Ki value of 2.43 +/- 0.70 …
The concentration-dependent inhibition of binding of [125I]ET-1 by unlabeled ET-1, in spinal cord membranes showed an IC50 value of 2.66 +/- …
Characteristics of endothelin receptors in the cerebral cortex and spinal cord of aged rats.
Bertelsen GA, Rebello S, Gulati A. Bertelsen GA, et al. Neurobiol Aging. 1992 Jul-Aug;13(4):513-9. doi: 10.1016/0197-4580(92)90080-h. Neurobiol Aging. 1992. PMID: 1324438
Characteristics of endothelin receptors were studied in male Fischer 344 rats at 4-, 15- and 24-months of age and [125I]ET-1 binding showed a single high affinity binding site in their cerebral cortex and spinal cord membranes. ...It is inferred that there are two subtypes …
Characteristics of endothelin receptors were studied in male Fischer 344 rats at 4-, 15- and 24-months of age and [125I]ET-1 binding showed …
Ontogeny of endothelin and its receptors in rat brain.
Gulati A, Rebello S, Chari G, Bhat R. Gulati A, et al. Life Sci. 1992;51(22):1715-24. doi: 10.1016/0024-3205(92)90300-e. Life Sci. 1992. PMID: 1435080
It is concluded that ET and its receptors are developmentally regulated and there is a possibility that endogenous ET is involved in the regulation of ET receptor density....
It is concluded that ET and its receptors are developmentally regulated and there is a possibility that endogenous ET is involved in …
Morphine metabolism in acutely ill preterm newborn infants.
Bhat R, Abu-Harb M, Chari G, Gulati A. Bhat R, et al. J Pediatr. 1992 May;120(5):795-9. doi: 10.1016/s0022-3476(05)80251-3. J Pediatr. 1992. PMID: 1578319
To examine the manner in which morphine is metabolized in acutely ill premature infants, we measured the levels of morphine, morphine-3- and -6-glucuronides, and codeine in timed urine specimens and paired plasma specimens at 4 hours and 24 hours after a single dose of mor …
To examine the manner in which morphine is metabolized in acutely ill premature infants, we measured the levels of morphine, morphine-3- and …
Binding characteristics of [3H]SCH 23390 in spinal cord and discrete brain regions of kappa-opiate tolerant-dependent and abstinent rats.
Bhargava HN, Gulati A, Ramarao P. Bhargava HN, et al. Pharmacology. 1991;42(3):121-7. doi: 10.1159/000138788. Pharmacology. 1991. PMID: 1647533
The effects of chronic administration of U-50,488H, a highly selective kappa-opiate receptor agonist, and its subsequent withdrawal were determined. ...Male Sprague-Dawley rats received U-50,488H (25 mg/kg) intraperitoneally twice a day for 4 days. Animals serving a …
The effects of chronic administration of U-50,488H, a highly selective kappa-opiate receptor agonist, and its subsequent withdrawal w …
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