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Unlimited multistability in multisite phosphorylation systems.
Thomson M, Gunawardena J. Thomson M, et al. Among authors: gunawardena j. Nature. 2009 Jul 9;460(7252):274-7. doi: 10.1038/nature08102. Epub 2009 Jun 17. Nature. 2009. PMID: 19536158 Free PMC article.
Multisite protein phosphorylation makes a good threshold but can be a poor switch.
Gunawardena J. Gunawardena J. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14617-22. doi: 10.1073/pnas.0507322102. Epub 2005 Sep 29. Proc Natl Acad Sci U S A. 2005. PMID: 16195377 Free PMC article.
Distributivity and processivity in multisite phosphorylation can be distinguished through steady-state invariants.
Gunawardena J. Gunawardena J. Biophys J. 2007 Dec 1;93(11):3828-34. doi: 10.1529/biophysj.107.110866. Epub 2007 Aug 17. Biophys J. 2007. PMID: 17704153 Free PMC article.
Programming with models: modularity and abstraction provide powerful capabilities for systems biology.
Mallavarapu A, Thomson M, Ullian B, Gunawardena J. Mallavarapu A, et al. Among authors: gunawardena j. J R Soc Interface. 2009 Mar 6;6(32):257-70. doi: 10.1098/rsif.2008.0205. J R Soc Interface. 2009. PMID: 18647734 Free PMC article.
The geometry of multisite phosphorylation.
Manrai AK, Gunawardena J. Manrai AK, et al. Among authors: gunawardena j. Biophys J. 2008 Dec 15;95(12):5533-43. doi: 10.1529/biophysj.108.140632. Epub 2008 Oct 10. Biophys J. 2008. PMID: 18849417 Free PMC article.
The rational parameterization theorem for multisite post-translational modification systems.
Thomson M, Gunawardena J. Thomson M, et al. Among authors: gunawardena j. J Theor Biol. 2009 Dec 21;261(4):626-36. doi: 10.1016/j.jtbi.2009.09.003. Epub 2009 Sep 16. J Theor Biol. 2009. PMID: 19765594 Free PMC article.
Evolutionary constraints of phosphorylation in eukaryotes, prokaryotes, and mitochondria.
Gnad F, Forner F, Zielinska DF, Birney E, Gunawardena J, Mann M. Gnad F, et al. Among authors: gunawardena j. Mol Cell Proteomics. 2010 Dec;9(12):2642-53. doi: 10.1074/mcp.M110.001594. Epub 2010 Aug 5. Mol Cell Proteomics. 2010. PMID: 20688971 Free PMC article.
Comparative analysis of Erk phosphorylation suggests a mixed strategy for measuring phospho-form distributions.
Prabakaran S, Everley RA, Landrieu I, Wieruszeski JM, Lippens G, Steen H, Gunawardena J. Prabakaran S, et al. Among authors: gunawardena j. Mol Syst Biol. 2011 Apr 12;7:482. doi: 10.1038/msb.2011.15. Mol Syst Biol. 2011. PMID: 21487401 Free PMC article.
A linear framework for time-scale separation in nonlinear biochemical systems.
Gunawardena J. Gunawardena J. PLoS One. 2012;7(5):e36321. doi: 10.1371/journal.pone.0036321. Epub 2012 May 14. PLoS One. 2012. PMID: 22606254 Free PMC article.
Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited.
Xu Y, Gunawardena J. Xu Y, et al. Among authors: gunawardena j. J Theor Biol. 2012 Oct 21;311:139-52. doi: 10.1016/j.jtbi.2012.07.012. Epub 2012 Jul 22. J Theor Biol. 2012. PMID: 22828569 Free PMC article.
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