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51 results

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Page 1
Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug.
Okabe N, Wei X, Abumeri F, Batac J, Hovanesyan M, Dai W, Azarapetian S, Campagna J, Pilati N, Marasco A, Alvaro G, Gunthorpe MJ, Varghese J, Cramer SC, Mody I, Carmichael ST. Okabe N, et al. Among authors: gunthorpe mj. Nat Commun. 2025 Mar 15;16(1):2556. doi: 10.1038/s41467-025-57860-0. Nat Commun. 2025. PMID: 40089466 Free PMC article.
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function.
Al-Hosni R, Agostinelli E, Ilkan Z, Scofano L, Kaye R, Dinsdale RL, Acheson K, MacDonald A, Rivers D, Biosa A, Gunthorpe MJ, Platt F, Tammaro P. Al-Hosni R, et al. Among authors: gunthorpe mj. Br J Pharmacol. 2025 Apr;182(8):1719-1740. doi: 10.1111/bph.17383. Epub 2025 Jan 19. Br J Pharmacol. 2025. PMID: 39829151
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M. Liang Q, et al. Among authors: gunthorpe mj. Nat Commun. 2024 Mar 21;15(1):2533. doi: 10.1038/s41467-024-46813-8. Nat Commun. 2024. PMID: 38514618 Free PMC article.
Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy.
Feng H, Clatot J, Kaneko K, Flores-Mendez M, Wengert ER, Koutcher C, Hoddeson E, Lopez E, Lee D, Arias L, Liang Q, Zhang X, Somarowthu A, Covarrubias M, Gunthorpe MJ, Large CH, Akizu N, Goldberg EM. Feng H, et al. Among authors: gunthorpe mj. Cell Rep Med. 2024 Feb 20;5(2):101389. doi: 10.1016/j.xcrm.2023.101389. Epub 2024 Jan 23. Cell Rep Med. 2024. PMID: 38266642 Free PMC article.
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, Burr K, Davies C, Colom-Cadena M, Chandran S, Large CH, Rowan MJM, Gunthorpe MJ, Spires-Jones TL. Yeap J, et al. Among authors: gunthorpe mj. Brain Neurosci Adv. 2022 Mar 24;6:23982128221086464. doi: 10.1177/23982128221086464. eCollection 2022 Jan-Dec. Brain Neurosci Adv. 2022. PMID: 35359460 Free PMC article.
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Davies DJ, Crowe M, Lucas N, Quinn J, Miller DD, Pritchard S, Grose D, Bettini E, Calcinaghi N, Virginio C, Abberley L, Goldsmith P, Michel AD, Chessell IP, Kew JN, Miller ND, Gunthorpe MJ. Davies DJ, et al. Among authors: gunthorpe mj. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2620-3. doi: 10.1016/j.bmcl.2012.01.108. Epub 2012 Feb 6. Bioorg Med Chem Lett. 2012. PMID: 22366657
51 results