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The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. Shimizu K, et al. Among authors: guo a. Sci Signal. 2017 Jan 3;10(460):eaah4117. doi: 10.1126/scisignal.aah4117. Sci Signal. 2017. PMID: 28049764 Free PMC article.
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.
Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W. Guo J, et al. Among authors: guo a. Nat Cell Biol. 2019 Feb;21(2):226-237. doi: 10.1038/s41556-018-0261-6. Epub 2019 Jan 28. Nat Cell Biol. 2019. PMID: 30692625 Free PMC article.
Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases.
Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, Comb MJ. Moritz A, et al. Among authors: guo a. Sci Signal. 2010 Aug 24;3(136):ra64. doi: 10.1126/scisignal.2000998. Sci Signal. 2010. PMID: 20736484 Free PMC article.
Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Kim W, et al. Among authors: guo a. Mol Cell. 2011 Oct 21;44(2):325-40. doi: 10.1016/j.molcel.2011.08.025. Epub 2011 Sep 8. Mol Cell. 2011. PMID: 21906983 Free PMC article.
Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Emanuele MJ, et al. Among authors: guo a. Cell. 2011 Oct 14;147(2):459-74. doi: 10.1016/j.cell.2011.09.019. Epub 2011 Sep 29. Cell. 2011. PMID: 21963094 Free PMC article.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ. Rush J, et al. Among authors: guo a. Nat Biotechnol. 2005 Jan;23(1):94-101. doi: 10.1038/nbt1046. Epub 2004 Dec 12. Nat Biotechnol. 2005. PMID: 15592455
Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9.
Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T. Hamidi T, et al. Among authors: guo a. J Biol Chem. 2018 Aug 17;293(33):12770-12780. doi: 10.1074/jbc.RA118.002890. Epub 2018 Jun 29. J Biol Chem. 2018. PMID: 29959229 Free PMC article.
2,210 results