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Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT. Hansch C, et al. Among authors: guo zr. J Med Chem. 1984 Feb;27(2):129-43. doi: 10.1021/jm00368a006. J Med Chem. 1984. PMID: 6420569
Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in making inferences about the mechanism of resistance and the structure of the enzyme is situ compared with the enzyme in vitro.
Coats EA, Genther CS, Dietrich SW, Guo ZR, Hansch C. Coats EA, et al. Among authors: guo zr. J Med Chem. 1981 Dec;24(12):1422-9. doi: 10.1021/jm00144a010. J Med Chem. 1981. PMID: 6796688
216 results