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13,599 results
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Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.
Gupta A, Vij G, Sharma S, Tirkey N, Rishi P, Chopra K. Gupta A, et al. Immunobiology. 2009;214(1):33-9. doi: 10.1016/j.imbio.2008.04.003. Epub 2008 Jun 17. Immunobiology. 2009. PMID: 19159825
This study is designed to evaluate the effect of natural polyphenol, curcumin, in a mouse model of immunologically induced fatigue, where purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens were used as immunogens. ...These findings strongly suggest that d …
This study is designed to evaluate the effect of natural polyphenol, curcumin, in a mouse model of immunologically induced fatigue, w …
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Kumar A, Sharma N, Gupta A, Kalonia H, Mishra J. Kumar A, et al. Among authors: gupta a. Brain Res. 2012 Aug 30;1471:13-22. doi: 10.1016/j.brainres.2012.06.050. Epub 2012 Jul 10. Brain Res. 2012. PMID: 22789904
Neuro-inflammation and oxidative stress plays a key role in the pathophysiology of Parkinson's disease (PD). Studies demonstrated that neuro-inflammation and associated infiltration of inflammatory cells into central nervous system are inhibited by 3-hydroxy-3-methyl gluta …
Neuro-inflammation and oxidative stress plays a key role in the pathophysiology of Parkinson's disease (PD). Studies demonstrated tha …
Effect of nitric oxide in protective effect of melatonin against chronic constriction sciatic nerve injury induced neuropathic pain in rats.
Kumar A, Meena S, Kalonia H, Gupta A, Kumar P. Kumar A, et al. Among authors: gupta a. Indian J Exp Biol. 2011 Sep;49(9):664-71. Indian J Exp Biol. 2011. PMID: 21941939
Developing a successful treatment strategy for neuropathic pain has remained a challenge among researcher and clinicians. Various animal models have been employed to understand the pathogenic mechanism of neuropathic pain in experimental animals. ...
Developing a successful treatment strategy for neuropathic pain has remained a challenge among researcher and clinicians. Vari …
Effect of preferential cyclooxygenase-2 (COX-2) inhibitor against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: behavioral, biochemical and histological evidences.
Gupta A, Dhir A, Kumar A, Kulkarni SK. Gupta A, et al. Indian J Exp Biol. 2010 Jun;48(6):577-85. Indian J Exp Biol. 2010. PMID: 20882760
The present study evaluated the neuroprotective effect of nimesulide, a preferential COX-2-inhibitor against 1-methyl-4-phenyl-1,2,3,6-tertahydropyridine (MPTP)-model of Parkinson's disease. Intrastriatal administration of MPTP (32 micromol in 2 microl) produced a s …
The present study evaluated the neuroprotective effect of nimesulide, a preferential COX-2-inhibitor against 1-methyl-4-phenyl-1,2,3, …
Licofelone attenuates MPTP-induced neuronal toxicity: behavioral, biochemical and cellular evidence.
Gupta A, Kumar A, Kulkarni SK. Gupta A, et al. Inflammopharmacology. 2010 Oct;18(5):223-32. doi: 10.1007/s10787-010-0052-6. Epub 2010 Aug 11. Inflammopharmacology. 2010. PMID: 20697819
Therefore, the present study is aimed to evaluate the possible role of licofelone, a dual COX/LOX-inhibitor against MPTP-induced neurotoxicity in mice. ...The findings of the present study suggest that licofelone (dual inhibitor of COX and LOX) represents a new clas …
Therefore, the present study is aimed to evaluate the possible role of licofelone, a dual COX/LOX-inhibitor against MPTP-induced neur …
Possible role of oxidative stress and immunological activation in mouse model of chronic fatigue syndrome and its attenuation by olive extract.
Gupta A, Vij G, Chopra K. Gupta A, et al. J Neuroimmunol. 2010 Sep 14;226(1-2):3-7. doi: 10.1016/j.jneuroim.2010.05.021. Epub 2010 May 26. J Neuroimmunol. 2010. PMID: 20537729
Based on these assumptions, the present study was designed to evaluate the effect of olive extract in a mouse model of immunologically-induced fatigue, wherein purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigen were used as immunogens. ...Concurrent treatm …
Based on these assumptions, the present study was designed to evaluate the effect of olive extract in a mouse model of immunologicall …
Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats.
Gupta A, Dhir A, Kumar A, Kulkarni SK. Gupta A, et al. Pharmacol Biochem Behav. 2009 Dec;94(2):219-26. doi: 10.1016/j.pbb.2009.07.018. Epub 2009 Aug 8. Pharmacol Biochem Behav. 2009. PMID: 19666045
Modulation of antigen-induced chronic fatigue in mouse model of water immersion stress by naringin, a polyphenolic antioxidant.
Vij G, Gupta A, Chopra K. Vij G, et al. Among authors: gupta a. Fundam Clin Pharmacol. 2009 Jun;23(3):331-7. doi: 10.1111/j.1472-8206.2009.00675.x. Epub 2009 Mar 11. Fundam Clin Pharmacol. 2009. PMID: 19469804
Based on this, this study was designed to evaluate the effect of naringin, a natural polyphenol, in a mouse model of immunologically-induced fatigue, wherein purified lipopolysaccharide (LPS) as well as Brucella abortus (BA) antigen was used as immunogens. ...Presen …
Based on this, this study was designed to evaluate the effect of naringin, a natural polyphenol, in a mouse model of immunolog …
Renoprotective effects of sesamol in ferric nitrilotriacetate-induced oxidative renal injury in rats.
Gupta A, Sharma S, Kaur I, Chopra K. Gupta A, et al. Basic Clin Pharmacol Toxicol. 2009 Apr;104(4):316-21. doi: 10.1111/j.1742-7843.2009.00381.x. Epub 2009 Feb 27. Basic Clin Pharmacol Toxicol. 2009. PMID: 19281599
Challenge with ferric nitrilotriacetate markedly increased the blood urea nitrogen and serum creatinine levels, which was coupled with a marked lipid peroxidation, reduced activity of glutathione and decreased total nitric oxide levels in rat kidneys. ...
Challenge with ferric nitrilotriacetate markedly increased the blood urea nitrogen and serum creatinine levels, which was coupled with a
Sodium nitroprusside and L-arginine attenuates ferric nitrilotriacetate-induced oxidative renal injury in rats.
Gupta A, Chander V, Sharma S, Chopra K. Gupta A, et al. Toxicology. 2007 Apr 11;232(3):183-91. doi: 10.1016/j.tox.2007.01.009. Epub 2007 Jan 16. Toxicology. 2007. PMID: 17280760
Pretreatment with SNP and L-Arg attenuated the levels of TNF-alpha in serum in a significant manner. Prior administration of L-NAME reversed the protective effects produced by SNP and L-Arg. Present findings strongly suggest that nitric oxide plays a significant rol …
Pretreatment with SNP and L-Arg attenuated the levels of TNF-alpha in serum in a significant manner. Prior administration of L-NAME r …
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