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Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion.
Gurgul-Convey E, Hanzelka K, Lenzen S. Gurgul-Convey E, et al. Endocrinology. 2012 Jun;153(6):2612-22. doi: 10.1210/en.2011-2027. Epub 2012 Apr 11. Endocrinology. 2012. PMID: 22495672
Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.
Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M. Lortz S, et al. Diabetologia. 2005 Aug;48(8):1541-8. doi: 10.1007/s00125-005-1822-3. Epub 2005 Jun 29. Diabetologia. 2005. PMID: 15986238
Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells.
Elsner M, Gurgul-Convey E, Lenzen S. Elsner M, et al. Free Radic Biol Med. 2006 Sep 1;41(5):825-34. doi: 10.1016/j.freeradbiomed.2006.06.002. Epub 2006 Jun 7. Free Radic Biol Med. 2006. PMID: 16895803
Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan.
Elsner M, Gurgul-Convey E, Lenzen S. Elsner M, et al. Antioxid Redox Signal. 2008 Apr;10(4):691-9. doi: 10.1089/ars.2007.1816. Antioxid Redox Signal. 2008. PMID: 18177230
Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells.
Souza KL, Gurgul-Convey E, Elsner M, Lenzen S. Souza KL, et al. J Endocrinol. 2008 Apr;197(1):139-50. doi: 10.1677/JOE-07-0638. J Endocrinol. 2008. PMID: 18372240
Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells.
Gurgul-Convey E, Lenzen S. Gurgul-Convey E, et al. J Biol Chem. 2010 Apr 9;285(15):11121-8. doi: 10.1074/jbc.M109.054775. Epub 2010 Feb 16. J Biol Chem. 2010. PMID: 20159982 Free PMC article.
Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria.
Gurgul-Convey E, Mehmeti I, Lortz S, Lenzen S. Gurgul-Convey E, et al. J Mol Med (Berl). 2011 Aug;89(8):785-98. doi: 10.1007/s00109-011-0747-1. Epub 2011 Apr 13. J Mol Med (Berl). 2011. PMID: 21487676
Differential effects of proinflammatory cytokines on cell death and ER stress in insulin-secreting INS1E cells and the involvement of nitric oxide.
Kacheva S, Lenzen S, Gurgul-Convey E. Kacheva S, et al. Cytokine. 2011 Aug;55(2):195-201. doi: 10.1016/j.cyto.2011.04.002. Epub 2011 Apr 29. Cytokine. 2011. PMID: 21531147
Induction of the intrinsic apoptosis pathway in insulin-secreting cells is dependent on oxidative damage of mitochondria but independent of caspase-12 activation.
Mehmeti I, Gurgul-Convey E, Lenzen S, Lortz S. Mehmeti I, et al. Biochim Biophys Acta. 2011 Oct;1813(10):1827-35. doi: 10.1016/j.bbamcr.2011.06.022. Epub 2011 Jul 8. Biochim Biophys Acta. 2011. PMID: 21784110
Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan.
Scullion SM, Gurgul-Convey E, Elsner M, Lenzen S, Flatt PR, McClenaghan NH. Scullion SM, et al. J Endocrinol. 2012 Aug;214(2):233-8. doi: 10.1530/JOE-11-0461. Epub 2012 May 11. J Endocrinol. 2012. PMID: 22582095
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