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A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis.
Dal Canto MC, Gurney ME. Dal Canto MC, et al. Among authors: gurney me. Acta Neuropathol. 1997 Jun;93(6):537-50. doi: 10.1007/s004010050650. Acta Neuropathol. 1997. PMID: 9194892
Immunohistochemical study on the distribution of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation.
Shin CM, Chung YH, Kim MJ, Shin DH, Kim YS, Gurney ME, Lee KW, Cha CI. Shin CM, et al. Among authors: gurney me. Brain Res. 2000 Dec 29;887(2):309-15. doi: 10.1016/s0006-8993(00)03014-6. Brain Res. 2000. PMID: 11134620
The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Hottinger AF, Fine EG, Gurney ME, Zurn AD, Aebischer P. Hottinger AF, et al. Among authors: gurney me. Eur J Neurosci. 1997 Jul;9(7):1548-51. doi: 10.1111/j.1460-9568.1997.tb01511.x. Eur J Neurosci. 1997. PMID: 9240414
Transgenic animal models of familial amyotrophic lateral sclerosis.
Gurney ME. Gurney ME. J Neurol. 1997 May;244 Suppl 2:S15-20. doi: 10.1007/BF03160575. J Neurol. 1997. PMID: 9178166
Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Chiu AY, Zhai P, Dal Canto MC, Peters TM, Kwon YW, Prattis SM, Gurney ME. Chiu AY, et al. Among authors: gurney me. Mol Cell Neurosci. 1995 Aug;6(4):349-62. doi: 10.1006/mcne.1995.1027. Mol Cell Neurosci. 1995. PMID: 8846004
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VM. Tu PH, et al. Among authors: gurney me. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3155-60. doi: 10.1073/pnas.93.7.3155. Proc Natl Acad Sci U S A. 1996. PMID: 8610185 Free PMC article.
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