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Cytotoxicity of cyclophosphamide, paclitaxel, and docetaxel for tumor cell lines in vitro: effects of concentration, time and cytochrome P450-catalyzed metabolism.
Gut I, Danielová V, Holubová J, Soucek P, Klucková H. Gut I, et al. Arch Toxicol. 2000 Oct;74(8):437-46. doi: 10.1007/s002040000141. Arch Toxicol. 2000. PMID: 11097380
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, Gut I. Vaclavikova R, et al. Among authors: gut i. Drug Metab Dispos. 2004 Jun;32(6):666-74. doi: 10.1124/dmd.32.6.666. Drug Metab Dispos. 2004. PMID: 15155559
Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants.
Václavíková R, Horský S, Simek P, Gut I. Václavíková R, et al. Among authors: gut i. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):200-9. doi: 10.1007/s00210-003-0781-9. Epub 2003 Aug 14. Naunyn Schmiedebergs Arch Pharmacol. 2003. PMID: 12920504
Different antioxidant effects of polyphenols on lipid peroxidation and hydroxyl radicals in the NADPH-, Fe-ascorbate- and Fe-microsomal systems.
Ozgová S, Hermánek J, Gut I. Ozgová S, et al. Among authors: gut i. Biochem Pharmacol. 2003 Oct 1;66(7):1127-37. doi: 10.1016/s0006-2952(03)00425-8. Biochem Pharmacol. 2003. PMID: 14505792
RNA expression of cytochrome P450 in breast cancer patients.
Vaclavikova R, Hubackova M, Stribrna-Sarmanova J, Kodet R, Mrhalova M, Novotny J, Gut I, Soucek P. Vaclavikova R, et al. Among authors: gut i. Anticancer Res. 2007 Nov-Dec;27(6C):4443-50. Anticancer Res. 2007. PMID: 18214058
New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals.
Soucek P, Kondrova E, Hermanek J, Stopka P, Boumendjel A, Ueng YF, Gut I. Soucek P, et al. Among authors: gut i. Anticancer Drugs. 2011 Feb;22(2):176-84. doi: 10.1097/cad.0b013e328341a17b. Anticancer Drugs. 2011. PMID: 21218605
Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells.
Ehrlichová M, Ojima I, Chen J, Václavíková R, Němcová-Fürstová V, Vobořilová J, Simek P, Horský S, Souček P, Kovář J, Brabec M, Gut I. Ehrlichová M, et al. Among authors: gut i. Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):1035-48. doi: 10.1007/s00210-012-0785-4. Epub 2012 Aug 2. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22855252
Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes.
Otová B, Ojima I, Václavíková R, Hrdý J, Ehrlichová M, Souček P, Vobořilová J, Němcová V, Zanardi I, Horský S, Kovář J, Gut I. Otová B, et al. Among authors: gut i. Invest New Drugs. 2012 Jun;30(3):991-1002. doi: 10.1007/s10637-011-9654-0. Epub 2011 Mar 30. Invest New Drugs. 2012. PMID: 21448670
Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells.
Kovár J, Ehrlichová M, Smejkalová B, Zanardi I, Ojima I, Gut I. Kovár J, et al. Among authors: gut i. Anticancer Res. 2009 Aug;29(8):2951-60. Anticancer Res. 2009. PMID: 19661300 Free PMC article.
Effects of paclitaxel, docetaxel and their combinations on subcutaneous lymphomas in inbred Sprague-Dawley/Cub rats.
Otová B, Václavíková R, Danielová V, Holubová J, Ehrlichová M, Horský S, Soucek P, Simek P, Gut I. Otová B, et al. Among authors: gut i. Eur J Pharm Sci. 2006 Dec;29(5):442-50. doi: 10.1016/j.ejps.2006.08.007. Epub 2006 Aug 23. Eur J Pharm Sci. 2006. PMID: 17000091
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