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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.
Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, Phillips AG, Rubin EM, Hersch SM, Hayden MR. Hodgson JG, et al. Among authors: gutekunst ca. Neuron. 1999 May;23(1):181-92. doi: 10.1016/s0896-6273(00)80764-3. Neuron. 1999. PMID: 10402204 Free article.
Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.
Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. Among authors: gutekunst ca. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Among authors: gutekunst ca. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: gutekunst ca. Hum Mol Genet. 2003 Jul 1;12(13):1555-67. doi: 10.1093/hmg/ddg169. Hum Mol Genet. 2003. PMID: 12812983
Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.
Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR. Hackam AS, et al. Among authors: gutekunst ca. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29;354(1386):1047-55. doi: 10.1098/rstb.1999.0457. Philos Trans R Soc Lond B Biol Sci. 1999. PMID: 10434304 Free PMC article. Review.
Recent advances in Huntington's disease.
Gutekunst CA, Norflus F, Hersch SM. Gutekunst CA, et al. Curr Opin Neurol. 2000 Aug;13(4):445-50. doi: 10.1097/00019052-200008000-00013. Curr Opin Neurol. 2000. PMID: 10970063 Review.
74 results