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Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization.
Smith K, Crowe SR, Garman L, Guthridge CJ, Muther JJ, McKee E, Zheng NY, Farris AD, Guthridge JM, Wilson PC, James JA. Smith K, et al. Among authors: guthridge cj. Vaccine. 2012 Jun 13;30(28):4276-83. doi: 10.1016/j.vaccine.2012.03.002. Epub 2012 Mar 14. Vaccine. 2012. PMID: 22425791 Free PMC article.
Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus.
Kheir JM, Guthridge CJ, Johnston JR, Adams LJ, Rasmussen A, Gross TF, Munroe ME, Bourn RL, Sivils KL, Guthridge JM, Weisman MH, Wallace DJ, Anaya JM, Rojas Villarraga A, Jarvis JN, Harley JB, James JA. Kheir JM, et al. Among authors: guthridge cj. Lupus Sci Med. 2018 Feb 27;5(1):e000247. doi: 10.1136/lupus-2017-000247. eCollection 2018. Lupus Sci Med. 2018. PMID: 29531773 Free PMC article.
Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype.
Slight-Webb S, Smith M, Bylinska A, Macwana S, Guthridge C, Lu R, Merrill JT, Chakravarty E, Arriens C, Munroe ME, Maecker HT, Utz PJ, Guthridge JM, James JA. Slight-Webb S, et al. J Allergy Clin Immunol. 2020 Dec;146(6):1419-1433. doi: 10.1016/j.jaci.2020.04.047. Epub 2020 May 22. J Allergy Clin Immunol. 2020. PMID: 32446964 Free PMC article. Clinical Trial.
Antibody Responses to Epstein-Barr Virus in the Preclinical Period of Rheumatoid Arthritis Suggest the Presence of Increased Viral Reactivation Cycles.
Fechtner S, Berens H, Bemis E, Johnson RL, Guthridge CJ, Carlson NE, Demoruelle MK, Harley JB, Edison JD, Norris JA, Robinson WH, Deane KD, James JA, Holers VM. Fechtner S, et al. Among authors: guthridge cj. Arthritis Rheumatol. 2022 Apr;74(4):597-603. doi: 10.1002/art.41994. Epub 2022 Feb 13. Arthritis Rheumatol. 2022. PMID: 34605217 Free PMC article.
Serologic markers of Epstein-Barr virus reactivation are associated with increased disease activity, inflammation, and interferon pathway activation in patients with systemic lupus erythematosus.
Wood RA, Guthridge L, Thurmond E, Guthridge CJ, Kheir JM, Bourn RL, Wagner CA, Chen H, DeJager W, Macwana SR, Kamp S, Lu R, Arriens C, Chakravarty EF, Thanou A, Merrill JT, Guthridge JM, James JA. Wood RA, et al. Among authors: guthridge cj. J Transl Autoimmun. 2021 Aug 31;4:100117. doi: 10.1016/j.jtauto.2021.100117. eCollection 2021. J Transl Autoimmun. 2021. PMID: 35005588 Free PMC article.
Ancestry-based differences in the immune phenotype are associated with lupus activity.
Slight-Webb S, Thomas K, Smith M, Wagner CA, Macwana S, Bylinska A, Donato M, Dvorak M, Chang SE, Kuo A, Cheung P, Kalesinskas L, Ganesan A, Dermadi D, Guthridge CJ, DeJager W, Wright C, Foecke MH, Merrill JT, Chakravarty E, Arriens C, Maecker HT, Khatri P, Utz PJ, James JA, Guthridge JM. Slight-Webb S, et al. Among authors: guthridge cj. JCI Insight. 2023 Aug 22;8(16):e169584. doi: 10.1172/jci.insight.169584. JCI Insight. 2023. PMID: 37606045 Free PMC article.
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