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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B. Wheeler JM, et al. Among authors: guthrie c. Sci Transl Med. 2019 Dec 18;11(523):eaao6545. doi: 10.1126/scitranslmed.aao6545. Sci Transl Med. 2019. PMID: 31852801 Free PMC article.
Potential neuroprotective strategies against tauopathy.
Wheeler JM, Guthrie CR, Kraemer BC. Wheeler JM, et al. Among authors: guthrie cr. Biochem Soc Trans. 2012 Aug;40(4):656-60. doi: 10.1042/BST20120017. Biochem Soc Trans. 2012. PMID: 22817711 Free PMC article.
Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.
Watkins GR, Wang N, Mazalouskas MD, Gomez RJ, Guthrie CR, Kraemer BC, Schweiger S, Spiller BW, Wadzinski BE. Watkins GR, et al. Among authors: guthrie cr. J Biol Chem. 2012 Jul 13;287(29):24207-15. doi: 10.1074/jbc.M112.368613. Epub 2012 May 21. J Biol Chem. 2012. PMID: 22613722 Free PMC article.
282 results