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Sperm from mice genetically deficient for the PCSK4 proteinase exhibit accelerated capacitation, precocious acrosome reaction, reduced binding to egg zona pellucida, and impaired fertilizing ability.
Gyamera-Acheampong C, Tantibhedhyangkul J, Weerachatyanukul W, Tadros H, Xu H, van de Loo JW, Pelletier RM, Tanphaichitr N, Mbikay M. Gyamera-Acheampong C, et al. Biol Reprod. 2006 Apr;74(4):666-73. doi: 10.1095/biolreprod.105.046821. Epub 2005 Dec 21. Biol Reprod. 2006. PMID: 16371590
Plasma PCSK9 levels correlate with cholesterol in men but not in women.
Mayne J, Raymond A, Chaplin A, Cousins M, Kaefer N, Gyamera-Acheampong C, Seidah NG, Mbikay M, Chrétien M, Ooi TC. Mayne J, et al. Among authors: gyamera acheampong c. Biochem Biophys Res Commun. 2007 Sep 21;361(2):451-6. doi: 10.1016/j.bbrc.2007.07.029. Epub 2007 Jul 18. Biochem Biophys Res Commun. 2007. PMID: 17645871