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Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.
Häusler SF, Montalbán del Barrio I, Strohschein J, Chandran PA, Engel JB, Hönig A, Ossadnik M, Horn E, Fischer B, Krockenberger M, Heuer S, Seida AA, Junker M, Kneitz H, Kloor D, Klotz KN, Dietl J, Wischhusen J. Häusler SF, et al. Cancer Immunol Immunother. 2011 Oct;60(10):1405-18. doi: 10.1007/s00262-011-1040-4. Epub 2011 Jun 3. Cancer Immunol Immunother. 2011. PMID: 21638125
Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages - a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape.
Montalbán Del Barrio I, Penski C, Schlahsa L, Stein RG, Diessner J, Wöckel A, Dietl J, Lutz MB, Mittelbronn M, Wischhusen J, Häusler SFM. Montalbán Del Barrio I, et al. Among authors: hausler sfm. J Immunother Cancer. 2016 Aug 16;4:49. doi: 10.1186/s40425-016-0154-9. eCollection 2016. J Immunother Cancer. 2016. PMID: 27532024 Free PMC article.
Macrophage migration inhibitory factor expression in cervical cancer.
Krockenberger M, Engel JB, Kolb J, Dombrowsky Y, Häusler SF, Kohrenhagen N, Dietl J, Wischhusen J, Honig A. Krockenberger M, et al. Among authors: hausler sf. J Cancer Res Clin Oncol. 2010 May;136(5):651-7. doi: 10.1007/s00432-009-0702-5. Epub 2009 Nov 14. J Cancer Res Clin Oncol. 2010. PMID: 19915866
38 results