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2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.
Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. Ornstein PL, et al. Among authors: herin m. J Med Chem. 1998 Jan 29;41(3):358-78. doi: 10.1021/jm970498o. J Med Chem. 1998. PMID: 9464367
Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.
Monn JA, Massey SM, Valli MJ, Henry SS, Stephenson GA, Bures M, Hérin M, Catlow J, Giera D, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD. Monn JA, et al. Among authors: herin m. J Med Chem. 2007 Jan 25;50(2):233-40. doi: 10.1021/jm060917u. J Med Chem. 2007. PMID: 17228865
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
Monn JA, Valli MJ, Massey SM, Hao J, Reinhard MR, Bures MG, Heinz BA, Wang X, Carter JH, Getman BG, Stephenson GA, Herin M, Catlow JT, Swanson S, Johnson BG, McKinzie DL, Henry SS. Monn JA, et al. Among authors: herin m. J Med Chem. 2013 Jun 13;56(11):4442-55. doi: 10.1021/jm4000165. Epub 2013 Jun 3. J Med Chem. 2013. PMID: 23675965
Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
Bueno AB, Collado I, de Dios A, Domínguez C, Martín JA, Martín LM, Martínez-Grau MA, Montero C, Pedregal C, Catlow J, Coffey DS, Clay MP, Dantzig AH, Lindstrom T, Monn JA, Jiang H, Schoepp DD, Stratford RE, Tabas LB, Tizzano JP, Wright RA, Herin MF. Bueno AB, et al. Among authors: herin mf. J Med Chem. 2005 Aug 11;48(16):5305-20. doi: 10.1021/jm050235r. J Med Chem. 2005. PMID: 16078848
Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
Rorick-Kehn LM, Johnson BG, Burkey JL, Wright RA, Calligaro DO, Marek GJ, Nisenbaum ES, Catlow JT, Kingston AE, Giera DD, Herin MF, Monn JA, McKinzie DL, Schoepp DD. Rorick-Kehn LM, et al. Among authors: herin mf. J Pharmacol Exp Ther. 2007 Apr;321(1):308-17. doi: 10.1124/jpet.106.110809. Epub 2007 Jan 4. J Pharmacol Exp Ther. 2007. PMID: 17204749
Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19.
Gupta N, Settle L, Brown BR, Armaignac DL, Baram M, Perkins NE, Kaufman M, Melamed RR, Christie AB, Danesh VC, Denson JL, Cheruku SR, Boman K, Bansal V, Kumar VK, Walkey AJ, Domecq JP, Kashyap R, Aston CE; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Gupta N, et al. Crit Care Med. 2022 Oct 1;50(10):e744-e758. doi: 10.1097/CCM.0000000000005627. Epub 2022 Jul 27. Crit Care Med. 2022. PMID: 35894609 Free PMC article.
Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry.
Bhalala US, Gist KM, Tripathi S, Boman K, Kumar VK, Retford L, Chiotos K, Blatz AM, Dapul H, Verma S, Sayed IA, Gharpure VP, Bjornstad E, Tofil N, Irby K, Sanders RC Jr, Heneghan JA, Thomas M, Gupta MK, Oulds FE, Arteaga GM, Levy ER, Gupta N, Kaufman M, Abdelaty A, Shlomovich M, Medar SS, Iqbal O'Meara AM, Kuehne J, Menon S, Khandhar PB, Miller AS, Barry SM, Danesh VC, Khanna AK, Zammit K, Stulce C, McGonagill PW, Bercow A, Amzuta IG, Gupta S, Almazyad MA, Pierre L, Sendi P, Ishaque S, Anderson HL 3rd, Nawathe P, Akhter M, Lyons PG, Chen C, Walkey AJ, Bihorac A, Wada Bello I, Ben Ari J, Kovacevic T, Bansal V, Brinton JT, Zimmerman JJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Bhalala US, et al. Crit Care Med. 2022 Jan 1;50(1):e40-e51. doi: 10.1097/CCM.0000000000005232. Crit Care Med. 2022. PMID: 34387240 Free PMC article.
The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children With COVID-19.
Tripathi S, Christison AL, Levy E, McGravery J, Tekin A, Bolliger D, Kumar VK, Bansal V, Chiotos K, Gist KM, Dapul HR, Bhalala US, Gharpure VP, Heneghan JA, Gupta N, Bjornstad EC, Montgomery VL, Walkey A, Kashyap R, Arteaga GM; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Tripathi S, et al. Hosp Pediatr. 2021 Nov;11(11):e297-e316. doi: 10.1542/hpeds.2021-006087. Epub 2021 Jun 24. Hosp Pediatr. 2021. PMID: 34168067
40 results