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Multicomponent Lyme vaccine: three is not a crowd.
Brown EL, Kim JH, Reisenbichler ES, Höök M. Brown EL, et al. Vaccine. 2005 May 25;23(28):3687-96. doi: 10.1016/j.vaccine.2005.02.006. Vaccine. 2005. PMID: 15882529
BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding.
Kim JH, Singvall J, Schwarz-Linek U, Johnson BJ, Potts JR, Höök M. Kim JH, et al. J Biol Chem. 2004 Oct 1;279(40):41706-14. doi: 10.1074/jbc.M401691200. Epub 2004 Jul 29. J Biol Chem. 2004. PMID: 15292204
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.
Hyde JA, Weening EH, Chang M, Trzeciakowski JP, Höök M, Cirillo JD, Skare JT. Hyde JA, et al. Mol Microbiol. 2011 Oct;82(1):99-113. doi: 10.1111/j.1365-2958.2011.07801.x. Epub 2011 Aug 30. Mol Microbiol. 2011. PMID: 21854463 Free PMC article.
A novel fibronectin binding motif in MSCRAMMs targets F3 modules.
Prabhakaran S, Liang X, Skare JT, Potts JR, Höök M. Prabhakaran S, et al. PLoS One. 2009;4(4):e5412. doi: 10.1371/journal.pone.0005412. Epub 2009 Apr 30. PLoS One. 2009. PMID: 19404402 Free PMC article.
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection.
Weening EH, Parveen N, Trzeciakowski JP, Leong JM, Höök M, Skare JT. Weening EH, et al. Infect Immun. 2008 Dec;76(12):5694-705. doi: 10.1128/IAI.00690-08. Epub 2008 Sep 22. Infect Immun. 2008. PMID: 18809667 Free PMC article.
MSCRAMM--targeted vaccines and immunotherapy for staphylococcal infection.
Rivas JM, Speziale P, Patti JM, Höök M. Rivas JM, et al. Curr Opin Drug Discov Devel. 2004 Mar;7(2):223-7. Curr Opin Drug Discov Devel. 2004. PMID: 15603256 Review.
Resistance to Lyme disease in decorin-deficient mice.
Brown EL, Wooten RM, Johnson BJ, Iozzo RV, Smith A, Dolan MC, Guo BP, Weis JJ, Höök M. Brown EL, et al. J Clin Invest. 2001 Apr;107(7):845-52. doi: 10.1172/JCI11692. J Clin Invest. 2001. PMID: 11285303 Free PMC article.
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