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Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase.
Schäfer A, Högger P. Schäfer A, et al. Among authors: hogger p. Diabetes Res Clin Pract. 2007 Jul;77(1):41-6. doi: 10.1016/j.diabres.2006.10.011. Epub 2006 Nov 13. Diabetes Res Clin Pract. 2007. PMID: 17098323
Cellular pharmacodynamic effects of Pycnogenol® in patients with severe osteoarthritis: a randomized controlled pilot study.
Jessberger S, Högger P, Genest F, Salter DM, Seefried L. Jessberger S, et al. Among authors: hogger p. BMC Complement Altern Med. 2017 Dec 16;17(1):537. doi: 10.1186/s12906-017-2044-1. BMC Complement Altern Med. 2017. PMID: 29246219 Free PMC article. Clinical Trial.
Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol).
Uhlenhut K, Högger P. Uhlenhut K, et al. Among authors: hogger p. Free Radic Biol Med. 2012 Jul 15;53(2):305-13. doi: 10.1016/j.freeradbiomed.2012.04.013. Epub 2012 Apr 23. Free Radic Biol Med. 2012. PMID: 22569413
Single and multiple dose pharmacokinetics of maritime pine bark extract (pycnogenol) after oral administration to healthy volunteers.
Grimm T, Skrabala R, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Grimm T, et al. Among authors: hogger p. BMC Clin Pharmacol. 2006 Aug 3;6:4. doi: 10.1186/1472-6904-6-4. BMC Clin Pharmacol. 2006. PMID: 16887024 Free PMC article.
Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol).
Grimm T, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Grimm T, et al. Among authors: hogger p. J Inflamm (Lond). 2006 Jan 27;3:1. doi: 10.1186/1476-9255-3-1. J Inflamm (Lond). 2006. PMID: 16441890 Free PMC article.
Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol).
Schäfer A, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Schäfer A, et al. Among authors: hogger p. Biomed Pharmacother. 2006 Jan;60(1):5-9. doi: 10.1016/j.biopha.2005.08.006. Epub 2005 Oct 26. Biomed Pharmacother. 2006. PMID: 16330178 Clinical Trial.
Only 30 min after ingestion of the pine bark extract the serum samples induced a statistically significant increase in the inhibition of both COX-1 (P < 0.02) and COX-2 (P < 0.002). ...
Only 30 min after ingestion of the pine bark extract the serum samples induced a statistically significant increase in the inhibition of bot …
Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol).
Grimm T, Schäfer A, Högger P. Grimm T, et al. Among authors: hogger p. Free Radic Biol Med. 2004 Mar 15;36(6):811-22. doi: 10.1016/j.freeradbiomed.2003.12.017. Free Radic Biol Med. 2004. PMID: 14990359
Profiling a gut microbiota-generated catechin metabolite's fate in human blood cells using a metabolomic approach.
Mülek M, Fekete A, Wiest J, Holzgrabe U, Mueller MJ, Högger P. Mülek M, et al. Among authors: hogger p. J Pharm Biomed Anal. 2015 Oct 10;114:71-81. doi: 10.1016/j.jpba.2015.04.042. Epub 2015 May 8. J Pharm Biomed Anal. 2015. PMID: 26025814
Facilitated uptake of a bioactive metabolite of maritime pine bark extract (pycnogenol) into human erythrocytes.
Kurlbaum M, Mülek M, Högger P. Kurlbaum M, et al. Among authors: hogger p. PLoS One. 2013 Apr 30;8(4):e63197. doi: 10.1371/journal.pone.0063197. Print 2013. PLoS One. 2013. PMID: 23646194 Free PMC article.
Plasma protein binding of polyphenols from maritime pine bark extract (USP).
Kurlbaum M, Högger P. Kurlbaum M, et al. Among authors: hogger p. J Pharm Biomed Anal. 2011 Jan 5;54(1):127-32. doi: 10.1016/j.jpba.2010.07.038. Epub 2010 Aug 6. J Pharm Biomed Anal. 2011. PMID: 20732774
The flavonoids catechin and taxifolin revealed highest plasma protein binding of close to 100%, followed by procyanidin B1 and the cinnamic acid derivates ferulic acid (73.5 ± 0.12%), caffeic acid (66.0 ± 0.23%) and p-cumaric acid (65.4 ± 4.84%). Lower protein binding was …
The flavonoids catechin and taxifolin revealed highest plasma protein binding of close to 100%, followed by procyanidin B1 and the cinnamic …
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