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Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.
Larose H, Prokoph N, Matthews JD, Schlederer M, Högler S, Alsulami AF, Ducray SP, Nuglozeh E, Fazaludeen FMS, Elmouna A, Ceccon M, Mologni L, Gambacorti-Passerini C, Hoefler G, Lobello C, Pospisilova S, Janikova A, Woessmann W, Damm-Welk C, Zimmermann M, Federova A, Malone A, Smith O, Wasik M, Inghirami G, Lamant L, Blundell TL, Klapper W, Merkel O, Burke AGA, Mian S, Ashankyty I, Kenner L, Turner SD. Larose H, et al. Among authors: hogler s. Haematologica. 2021 Jun 1;106(6):1693-1704. doi: 10.3324/haematol.2019.238766. Haematologica. 2021. PMID: 32327503 Free PMC article.
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status.
Trigg RM, Lee LC, Prokoph N, Jahangiri L, Reynolds CP, Amos Burke GA, Probst NA, Han M, Matthews JD, Lim HK, Manners E, Martinez S, Pastor J, Blanco-Aparicio C, Merkel O, de Los Fayos Alonso IG, Kodajova P, Tangermann S, Högler S, Luo J, Kenner L, Turner SD. Trigg RM, et al. Among authors: hogler s. Nat Commun. 2019 Nov 28;10(1):5428. doi: 10.1038/s41467-019-13315-x. Nat Commun. 2019. PMID: 31780656 Free PMC article.
KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.
Limberger T, Schlederer M, Trachtová K, Garces de Los Fayos Alonso I, Yang J, Högler S, Sternberg C, Bystry V, Oppelt J, Tichý B, Schmeidl M, Kodajova P, Jäger A, Neubauer HA, Oberhuber M, Schmalzbauer BS, Pospisilova S, Dolznig H, Wadsak W, Culig Z, Turner SD, Egger G, Lagger S, Kenner L. Limberger T, et al. Among authors: hogler s. Mol Cancer. 2022 Mar 30;21(1):89. doi: 10.1186/s12943-022-01542-8. Mol Cancer. 2022. PMID: 35354467 Free PMC article.
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma.
Garces de Los Fayos Alonso I, Zujo L, Wiest I, Kodajova P, Timelthaler G, Edtmayer S, Zrimšek M, Kollmann S, Giordano C, Kothmayer M, Neubauer HA, Dey S, Schlederer M, Schmalzbauer BS, Limberger T, Probst C, Pusch O, Högler S, Tangermann S, Merkel O, Schiefer AI, Kornauth C, Prutsch N, Zimmerman M, Abraham B, Anagnostopoulos J, Quintanilla-Martinez L, Mathas S, Wolf P, Stoiber D, Staber PB, Egger G, Klapper W, Woessmann W, Look TA, Gunning P, Turner SD, Moriggl R, Lagger S, Kenner L. Garces de Los Fayos Alonso I, et al. Among authors: hogler s. Mol Cancer. 2022 Aug 31;21(1):172. doi: 10.1186/s12943-022-01640-7. Mol Cancer. 2022. PMID: 36045346 Free PMC article.
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat JP, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L. Oberhuber M, et al. Among authors: hogler s. Mol Syst Biol. 2020 Apr;16(4):e9247. doi: 10.15252/msb.20199247. Mol Syst Biol. 2020. PMID: 32323921 Free PMC article.
A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors.
Tobias J, Battin C, De Sousa Linhares A, Lebens M, Baier K, Ambroz K, Drinić M, Högler S, Inic-Kanada A, Garner-Spitzer E, Preusser M, Kenner L, Kundi M, Zielinski CC, Steinberger P, Wiedermann U. Tobias J, et al. Among authors: hogler s. Front Immunol. 2020 May 27;11:895. doi: 10.3389/fimmu.2020.00895. eCollection 2020. Front Immunol. 2020. PMID: 32528470 Free PMC article.
The Tyrosine Kinase Tec Regulates Effector Th17 Differentiation, Pathogenicity, and Plasticity in T-Cell-Driven Intestinal Inflammation.
Sandner L, Alteneder M, Zhu C, Hladik A, Högler S, Rica R, Van Greuningen LW, Sharif O, Sakaguchi S, Knapp S, Kenner L, Trauner M, Ellmeier W, Boucheron N. Sandner L, et al. Among authors: hogler s. Front Immunol. 2021 Dec 21;12:750466. doi: 10.3389/fimmu.2021.750466. eCollection 2021. Front Immunol. 2021. PMID: 35003062 Free PMC article.
Active immunization with a Her-2/neu-targeting Multi-peptide B cell vaccine prevents lung metastases formation from Her-2/neu breast cancer in a mouse model.
Tobias J, Drinić M, Högler S, Ambroz K, Baier K, Kodajova P, Tomasich E, Berghoff AS, Schmid A, Garner-Spitzer E, Kenner L, Kundi M, Zielinski CC, Wiedermann U. Tobias J, et al. Among authors: hogler s. Transl Oncol. 2022 May;19:101378. doi: 10.1016/j.tranon.2022.101378. Epub 2022 Mar 5. Transl Oncol. 2022. PMID: 35259675 Free PMC article.
Development and In Vivo Evaluation of Small-Molecule Ligands for Positron Emission Tomography of Immune Checkpoint Modulation Targeting Programmed Cell Death 1 Ligand 1.
Bamminger K, Pichler V, Vraka C, Limberger T, Moneva B, Pallitsch K, Lieder B, Zacher AS, Ponti S, Benčurová K, Yang J, Högler S, Kodajova P, Kenner L, Hacker M, Wadsak W. Bamminger K, et al. Among authors: hogler s. J Med Chem. 2024 Mar 14;67(5):4036-4062. doi: 10.1021/acs.jmedchem.3c02342. Epub 2024 Mar 5. J Med Chem. 2024. PMID: 38442487 Free PMC article.
Motor Cortex and Hippocampus Display Decreased Heme Oxygenase Activity 2 Weeks After Ventricular Fibrillation Cardiac Arrest in Rats.
Warenits AM, Hatami J, Müllebner A, Ettl F, Teubenbacher U, Magnet IAM, Bauder B, Janata A, Miller I, Moldzio R, Kramer AM, Sterz F, Holzer M, Högler S, Weihs W, Duvigneau JC. Warenits AM, et al. Among authors: hogler s. Front Med (Lausanne). 2020 Sep 10;7:513. doi: 10.3389/fmed.2020.00513. eCollection 2020. Front Med (Lausanne). 2020. PMID: 33015090 Free PMC article.
43 results