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Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy.
Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. Kimura K, et al. Among authors: hohfeld j. Nat Commun. 2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7. Nat Commun. 2021. PMID: 34117258 Free PMC article.
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.
Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J. Kathage B, et al. Among authors: hohfeld j. Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 27756573 Free article.
Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.
Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J. Ulbricht A, et al. Among authors: hohfeld j. Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21. Curr Biol. 2013. PMID: 23434281 Free article.
Chaperone-assisted selective autophagy is essential for muscle maintenance.
Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J. Arndt V, et al. Among authors: hohfeld j. Curr Biol. 2010 Jan 26;20(2):143-8. doi: 10.1016/j.cub.2009.11.022. Epub 2010 Jan 7. Curr Biol. 2010. PMID: 20060297 Free article.
Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. Höhfeld J, et al. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507. Epub 2021 Jul 26. EMBO Rep. 2021. PMID: 34309183 Free PMC article. Review.
Coordinated alpha-crystallin B phosphorylation and desmin expression indicate adaptation and deadaptation to resistance exercise-induced loading in human skeletal muscle.
Jacko D, Bersiner K, Schulz O, Przyklenk A, Spahiu F, Höhfeld J, Bloch W, Gehlert S. Jacko D, et al. Among authors: hohfeld j. Am J Physiol Cell Physiol. 2020 Aug 1;319(2):C300-C312. doi: 10.1152/ajpcell.00087.2020. Epub 2020 Jun 10. Am J Physiol Cell Physiol. 2020. PMID: 32520607 Free article.
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