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uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.
Kjøller L, Engelholm LH, Høyer-Hansen M, Danø K, Bugge TH, Behrendt N. Kjøller L, et al. Exp Cell Res. 2004 Feb 1;293(1):106-16. doi: 10.1016/j.yexcr.2003.10.008. Exp Cell Res. 2004. PMID: 14729061
Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
Daugaard M, Kirkegaard-Sørensen T, Ostenfeld MS, Aaboe M, Høyer-Hansen M, Orntoft TF, Rohde M, Jäättelä M. Daugaard M, et al. Cancer Res. 2007 Mar 15;67(6):2559-67. doi: 10.1158/0008-5472.CAN-06-4121. Cancer Res. 2007. PMID: 17363574
Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.
Groth-Pedersen L, Ostenfeld MS, Høyer-Hansen M, Nylandsted J, Jäättelä M. Groth-Pedersen L, et al. Cancer Res. 2007 Mar 1;67(5):2217-25. doi: 10.1158/0008-5472.CAN-06-3520. Cancer Res. 2007. PMID: 17332352
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.
Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, Mathiasen IS, Jäättelä M. Høyer-Hansen M, et al. Mol Cell. 2007 Jan 26;25(2):193-205. doi: 10.1016/j.molcel.2006.12.009. Mol Cell. 2007. PMID: 17244528
Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.
Gyrd-Hansen M, Farkas T, Fehrenbacher N, Bastholm L, Høyer-Hansen M, Elling F, Wallach D, Flavell R, Kroemer G, Nylandsted J, Jäättelä M. Gyrd-Hansen M, et al. Mol Cell Biol. 2006 Nov;26(21):7880-91. doi: 10.1128/MCB.00716-06. Epub 2006 Sep 11. Mol Cell Biol. 2006. PMID: 16966373 Free PMC article.
Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.
Ostenfeld MS, Fehrenbacher N, Høyer-Hansen M, Thomsen C, Farkas T, Jäättelä M. Ostenfeld MS, et al. Cancer Res. 2005 Oct 1;65(19):8975-83. doi: 10.1158/0008-5472.CAN-05-0269. Cancer Res. 2005. PMID: 16204071
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
Nylandsted J, Gyrd-Hansen M, Danielewicz A, Fehrenbacher N, Lademann U, Høyer-Hansen M, Weber E, Multhoff G, Rohde M, Jäättelä M. Nylandsted J, et al. J Exp Med. 2004 Aug 16;200(4):425-35. doi: 10.1084/jem.20040531. J Exp Med. 2004. PMID: 15314073 Free PMC article.
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.
Høyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jäättelä M. Høyer-Hansen M, et al. Cell Death Differ. 2005 Oct;12(10):1297-309. doi: 10.1038/sj.cdd.4401651. Cell Death Differ. 2005. PMID: 15905882
Degradation of protein translation machinery by amino acid starvation-induced macroautophagy.
Gretzmeier C, Eiselein S, Johnson GR, Engelke R, Nowag H, Zarei M, Küttner V, Becker AC, Rigbolt KTG, Høyer-Hansen M, Andersen JS, Münz C, Murphy RF, Dengjel J. Gretzmeier C, et al. Among authors: hoyer hansen m. Autophagy. 2017 Jun 3;13(6):1064-1075. doi: 10.1080/15548627.2016.1274485. Epub 2017 Apr 28. Autophagy. 2017. PMID: 28453381 Free PMC article.
Autophagy: an emerging target for cancer therapy.
Høyer-Hansen M, Jäättelä M. Høyer-Hansen M, et al. Autophagy. 2008 Jul;4(5):574-80. doi: 10.4161/auto.5921. Epub 2008 Mar 17. Autophagy. 2008. PMID: 18362515 Review.
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