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H1-antihistamines for primary mast cell activation syndromes: a systematic review.
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A. Nurmatov UB, et al. Allergy. 2015 Sep;70(9):1052-61. doi: 10.1111/all.12672. Epub 2015 Jul 6. Allergy. 2015. PMID: 26095756
OBJECTIVES: To assess the effectiveness and safety of orally administered H1 -antihistamines in the treatment of primary MCAS compared with placebo and other pharmacologic treatments. ...All five of these studies were judged to be at moderate or high risk of …
OBJECTIVES: To assess the effectiveness and safety of orally administered H1 -antihistamines in the treatment of primary MC …
Insect Sting Anaphylaxis-Or Mastocytosis-Or Something Else?
Golden DBK, Carter MC. Golden DBK, et al. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1117-1123. doi: 10.1016/j.jaip.2019.01.014. J Allergy Clin Immunol Pract. 2019. PMID: 30961837 Review.
Elevated baseline serum tryptase level has been reported to correlate with clonal mast cell disease in patients with insect sting anaphylaxis but may also indicate one of several possible underlying syndromes, including mast cell activation syndrome (MCAS), familial hypert …
Elevated baseline serum tryptase level has been reported to correlate with clonal mast cell disease in patients with insect sting anaphylaxi …
A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at Scale data platform.
Jansen C, Rice BG, Wooton B, Howard J, Elmasri S, Rivera T, Shimoda LMN, Stokes AJ, Adra CN, Small-Howard AL, Turner H. Jansen C, et al. bioRxiv [Preprint]. 2025 Sep 4:2025.08.30.673232. doi: 10.1101/2025.08.30.673232. bioRxiv. 2025. PMID: 40950138 Free PMC article. Preprint.
MCS chronically suppress all arms of the pro-inflammatory mast cell response to stimulation (e.g., histamine, protease, lipid mediators, cytokines, chemokines). They may therefore outperform approaches such as H1, H2 and H4 inhibitors (antihistamines) …
MCS chronically suppress all arms of the pro-inflammatory mast cell response to stimulation (e.g., histamine, protease, lipid mediato …
Characteristics and outcomes of patients with pediatric-onset non-mastocytosis mast cell activation disorders: A CEREMAST study.
Weiss M, Rossignol J, Campeotto F, Foy E, Elbany C, Jaume L, Geroux L, Debeaupuis O, Neuraz A, Bekel L, Lezmi G, Bellon N, Méni C, Livideanu C, Madrange M, Condé D, Agopian J, Michot C, Villard-Truc F, Lachaux A, Greco C, Hadj-Rabia S, Dubreuil P, Hermine O, Bodemer C, Polivka L. Weiss M, et al. Pediatr Allergy Immunol. 2026 May;37(5):e70373. doi: 10.1111/pai.70373. Pediatr Allergy Immunol. 2026. PMID: 42149735 Free PMC article.
MCAD not fulfilling mastocytosis or all MCAS criteria are referred to as MCAD not otherwise specified (MCAD-NOS). The aim was to describe the clinical, laboratory characteristics and outcomes of the first pediatric-onset non-mastocytosis MCAD cohort. ...Before 3 years of a …
MCAD not fulfilling mastocytosis or all MCAS criteria are referred to as MCAD not otherwise specified (MCAD-NOS). The aim was to desc …
[Severe Mast Cell Activation Syndrome in a 15-year-old patient with an hypermobile Ehlers-Danlos syndrome].
Daens S, Grossin D, Hermanns-Lê T, Peeters D, Manicourt D. Daens S, et al. Rev Med Liege. 2018 Feb;73(2):61-64. Rev Med Liege. 2018. PMID: 29517867 Free article. French.
He suffers mainly from a severe mast cell activation syndrome (MCAS) with an overreaction of the skin to any kind of contact (water of the shower, clothes, bed sheets) but he has also fatigue, headaches, and rash. ...We finally introduce the original term of "MASED" to thi …
He suffers mainly from a severe mast cell activation syndrome (MCAS) with an overreaction of the skin to any kind of contact (water o …
Mast Cell Activation Syndrome and Mastocytosis: Initial Treatment Options and Long-Term Management.
Castells M, Butterfield J. Castells M, et al. J Allergy Clin Immunol Pract. 2019 Apr;7(4):1097-1106. doi: 10.1016/j.jaip.2019.02.002. J Allergy Clin Immunol Pract. 2019. PMID: 30961835 Review.
Patients with nonclonal MCAS may have chronic or episodic mast cell activation symptoms with an increase in serum tryptase and/or urinary metabolites of histamine, prostaglandin D2, and leukotrienes. Symptoms of MCAS and SM can be managed by blockade of media …
Patients with nonclonal MCAS may have chronic or episodic mast cell activation symptoms with an increase in serum tryptase and/or uri …
Management of Adult Patients with Gastrointestinal Symptoms from Food Hypersensitivity-Narrative Review.
Kanikowska A, Janisz S, Mańkowska-Wierzbicka D, Gabryel M, Dobrowolska A, Eder P. Kanikowska A, et al. J Clin Med. 2022 Dec 9;11(24):7326. doi: 10.3390/jcm11247326. J Clin Med. 2022. PMID: 36555942 Free PMC article. Review.
Eosinophilic gastrointestinal diseases are often caused by non-IgE-mediated food allergies, require endoscopic biopsy samples to confirm diagnosis and proper elimination diet often combined with steroids or proton pump inhibitor agents for treatment. Mast cell activation syndrome …
Eosinophilic gastrointestinal diseases are often caused by non-IgE-mediated food allergies, require endoscopic biopsy samples to confirm dia …