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Histone H1.5, a novel prostatic cancer marker: an immunohistochemical study.
Khachaturov V, Xiao GQ, Kinoshita Y, Unger PD, Burstein DE. Khachaturov V, et al. Hum Pathol. 2014 Oct;45(10):2115-9. doi: 10.1016/j.humpath.2014.06.015. Epub 2014 Jul 3. Hum Pathol. 2014. PMID: 25130394
Histone H1.5 (HH1.5) is a somatic subtype of the histone H1 family of linker proteins that are located in the nucleus and play a role in stabilizing higher-order chromatin structure, gene expression, DNA repair, and cell proliferation. ...Increased HH1.5 reactivity …
Histone H1.5 (HH1.5) is a somatic subtype of the histone H1 family of linker proteins that are located in the nucleus and play …
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, Kelleher NL, Staudt LM, Skoultchi AI, Keogh MC, Apostolou E, Mason CE, Imielinski M, Schlick T, David Y, Tsirigos A, Allis CD, Soshnev AA, Cesarman E, Melnick AM. Yusufova N, et al. Nature. 2021 Jan;589(7841):299-305. doi: 10.1038/s41586-020-3017-y. Epub 2020 Dec 9. Nature. 2021. PMID: 33299181 Free PMC article.
Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respectively) are highly recurrent in B cell lymphomas, but the pathogenic relevance of these mutations to cancer and the mechanisms that are i …
Mutations in the genes that encode H1 isoforms B-E (H1B, H1C, H1D and H1E; also known as H1-5, H1-2, H1-3 and H1-4, respective …
Linker histone H1.5 is an underestimated factor in differentiation and carcinogenesis.
Behrends M, Engmann O. Behrends M, et al. Environ Epigenet. 2020 Oct 3;6(1):dvaa013. doi: 10.1093/eep/dvaa013. eCollection 2020. Environ Epigenet. 2020. PMID: 33214908 Free PMC article. Review.
Human histone H1.5, in mice called H1b, belongs to the family of linker histones (H1), which are key players in chromatin organization. ...However, many functions of H1.5 are still poorly understood. In this review, we will summarize what is currently …
Human histone H1.5, in mice called H1b, belongs to the family of linker histones (H1), which are key players in chromatin orga …
Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-cirrhotic Patients: A Multicentric Study of 44 International Expert Centers.
Sousa Da Silva RX, Breuer E, Shankar S, Kawakatsu S, Hołówko W, Santos Coelho J, Jeddou H, Sugiura T, Ghallab M, Da Silva D, Watanabe G, Botea F, Sakai N, Addeo P, Tzedakis S, Bartsch F, Balcer K, Lim C, Werey F, Lopez-Lopez V, Peralta Montero L, Sanchez Claria R, Leiting J, Vachharajani N, Hopping E, Torres OJM, Hirano S, Andel D, Hagendoorn J, Psica A, Ravaioli M, Ahn KS, Reese T, Montes LA, Gunasekaran G, Alcázar C, Lim JH, Haroon M, Lu Q, Castaldi A, Orimo T, Moeckli B, Abadía T, Ruffolo L, Dib Hasan J, Ratti F, Kauffmann EF, de Wilde RF, Polak WG, Boggi U, Aldrighetti L, McCormack L, Hernandez-Alejandro R, Serrablo A, Toso C, Taketomi A, Gugenheim J, Dong J, Hanif F, Park JS, Ramia JM, Schwartz M, Ramisch D, De Oliveira ML, Oldhafer KJ, Kang KJ, Cescon M, Lodge P, Rinkes IHMB, Noji T, Thomson JE, Goh SK, Chapman WC, Cleary SP, Pekolj J, Regimbeau JM, Scatton O, Truant S, Lang H, Fuks D, Bachellier P, Ohtsuka M, Popescu I, Hasegawa K, Lesurtel M, Adam R, Cherqui D, Uesaka K, Boudjema K, Pinto-Marques H, Grąt M, Petrowsky H, Ebata T, Prachalias A, Robles-Campos R, Clavien PA. Sousa Da Silva RX, et al. Ann Surg. 2023 Nov 1;278(5):748-755. doi: 10.1097/SLA.0000000000006012. Epub 2023 Jul 19. Ann Surg. 2023. PMID: 37465950
Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5,8) were associated with higher cutoffs for bile leaks, but had superior oncologic outcomes, when compared to formal left hepatectomy (H1-4 o …
Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5, …
Molecular Mechanism of the Pin1-Histone H1 Interaction.
Jinasena D, Simmons R, Gyamfi H, Fitzkee NC. Jinasena D, et al. Biochemistry. 2019 Feb 12;58(6):788-798. doi: 10.1021/acs.biochem.8b01036. Epub 2018 Dec 18. Biochemistry. 2019. PMID: 30507159 Free PMC article.
This Pin1-histone H1 interaction plays a key role in pathogen response, in infection, and in cell cycle control; therefore, anti-Pin1 therapeutics are an important focus for treating infections as well as cancer. Each of the H1 histones (H1.0-H1.5) contains s …
This Pin1-histone H1 interaction plays a key role in pathogen response, in infection, and in cell cycle control; therefore, anti-Pin1 therap …
Native and tagged CENP-A histones are functionally inequivalent.
Bui M, Baek S, Bentahar RS, Melters DP, Dalal Y. Bui M, et al. Epigenetics Chromatin. 2024 Jun 2;17(1):19. doi: 10.1186/s13072-024-00543-9. Epigenetics Chromatin. 2024. PMID: 38825690 Free PMC article.
Additionally, these tagged CENP-A-containing nucleosomes have reduced centromeric incorporation at early G1 phase and poorly associates with linker histone H1.5 compared to native CENP-A nucleosomes. CONCLUSIONS: These data suggest expressing tagged versions of hist …
Additionally, these tagged CENP-A-containing nucleosomes have reduced centromeric incorporation at early G1 phase and poorly associates with …
Expression of H1.5 and PLZF in granulosa cell tumors and normal ovarian tissues: a short report.
Momeni M, Kalir T, Farag S, Chuang L, Fishman D, Burstein DE. Momeni M, et al. Cell Oncol (Dordr). 2014 Jun;37(3):229-34. doi: 10.1007/s13402-014-0174-8. Epub 2014 Jul 15. Cell Oncol (Dordr). 2014. PMID: 25023763

RESULTS: A statistically significant difference in the expression of H1.5 between the GCT and normal ovary groups was observed (p < 0.0001). Normal ovarian tissues were found to strongly express H1.5, whereas GCTs were found to weakly express this p

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RESULTS: A statistically significant difference in the expression of H1.5 between the GCT and normal ovary groups was observed …
Ras-AKT signaling represses the phosphorylation of histone H1.5 at threonine 10 via GSK3 to promote the progression of glioma.
Sang B, Sun J, Yang D, Xu Z, Wei Y. Sang B, et al. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2882-2890. doi: 10.1080/21691401.2019.1638795. Artif Cells Nanomed Biotechnol. 2019. PMID: 31307224 Free article.
Background: Histone H1.5 has been considered as a novel cancer marker as its expression is associated with various human cancers. The objective of this study was to explore the effects of H1.5 phosphorylation in Ras-driven growth and migr …
Background: Histone H1.5 has been considered as a novel cancer marker as its expression is associated with various huma …
Nano-Surveillance: Tracking Individual Molecules in a Sea of Chromatin.
Melters DP, Dalal Y. Melters DP, et al. J Mol Biol. 2021 Mar 19;433(6):166720. doi: 10.1016/j.jmb.2020.11.019. Epub 2020 Nov 20. J Mol Biol. 2021. PMID: 33221335 Free PMC article. Review.
Chromatin is the epigenomic platform for diverse nuclear processes such as DNA repair, replication, transcription, telomere, and centromere function. In cancer cells, mutations in key processes result in DNA amplification, chromosome translocations, and chromothripsis, sev …
Chromatin is the epigenomic platform for diverse nuclear processes such as DNA repair, replication, transcription, telomere, and centromere …
FoxP3 interacts with linker histone H1.5 to modulate gene expression and program Treg cell activity.
Mackey-Cushman SL, Gao J, Holmes DA, Nunoya JI, Wang R, Unutmaz D, Su L. Mackey-Cushman SL, et al. Genes Immun. 2011 Oct;12(7):559-67. doi: 10.1038/gene.2011.31. Epub 2011 Jun 9. Genes Immun. 2011. PMID: 21654845 Free PMC article.
We discovered that FoxP3 interacted with linker histone H1.5 via the leucine zipper (LZ) domain. Two independent IPEX patient-derived single residue mutations in the LZ of FoxP3 both abrogated its interaction with H1.5. Functionally, FoxP3 and H1 …
We discovered that FoxP3 interacted with linker histone H1.5 via the leucine zipper (LZ) domain. Two independent IPEX patient- …
35 results