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H1N1 influenza A virus neuraminidase modulates infectivity in mice.
Ferraris O, Escuret V, Bouscambert M, Casalegno JS, Jacquot F, Raoul H, Caro V, Valette M, Lina B, Ottmann M. Ferraris O, et al. Antiviral Res. 2012 Mar;93(3):374-80. doi: 10.1016/j.antiviral.2012.01.008. Epub 2012 Feb 1. Antiviral Res. 2012. PMID: 22321413
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obt …
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on …
In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus.
Zhi HJ, Zhu HY, Zhang YY, Lu Y, Li H, Chen DF. Zhi HJ, et al. Phytomedicine. 2019 Apr;57:105-116. doi: 10.1016/j.phymed.2018.12.009. Epub 2018 Dec 10. Phytomedicine. 2019. PMID: 30668313
Mice were challenged intranasally with influenza virus H1N1 (A/FM/1/47) 2 h before treatment. ...FESR efficiently decreased lung virus titers, reduced haemagglutinin (HA) titers and inhibited neuraminidase (NA) activities in lungs of IAV-
Mice were challenged intranasally with influenza virus H1N1 (A/FM/1/47) 2 h before treatment. ...FESR efficientl
Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase.
Broecker F, Zheng A, Suntronwong N, Sun W, Bailey MJ, Krammer F, Palese P. Broecker F, et al. J Virol. 2019 Aug 28;93(18):e00840-19. doi: 10.1128/JVI.00840-19. Print 2019 Sep 15. J Virol. 2019. PMID: 31375573 Free PMC article.
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). ...Our findings may assist in the efforts toward more effective influenza virus vaccines....
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). ...Our findings may as
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.
Liu Q, Xiong HR, Lu L, Liu YY, Luo F, Hou W, Yang ZQ. Liu Q, et al. Acta Pharmacol Sin. 2013 Aug;34(8):1075-83. doi: 10.1038/aps.2013.54. Epub 2013 Jun 17. Acta Pharmacol Sin. 2013. PMID: 23770981 Free PMC article.
AIM: To investigate the effects of arbidol hydrochloride (ARB), a widely used antiviral agent, on the inflammation induced by influenza virus. METHODS: MDCK cells were infected with seasonal influenza A/FM/1/47 (H1N1) or pandemic influenza
AIM: To investigate the effects of arbidol hydrochloride (ARB), a widely used antiviral agent, on the inflammation induced by influenza
Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.
Huang CT, Hung CY, Hseih YC, Chang CS, Velu AB, He YC, Huang YL, Chen TA, Chen TC, Lin CY, Lin YC, Shih SR, Dutta A. Huang CT, et al. Phytomedicine. 2019 Nov;64:152904. doi: 10.1016/j.phymed.2019.152904. Epub 2019 Apr 4. Phytomedicine. 2019. PMID: 31454654
In vivo activity was tested in H1N1 influenza virus infected mice. Aloin-mediated inhibition of influenza neuraminidase activity was tested by MUNANA assay. ...In H1N1 influenza virus infected mice
In vivo activity was tested in H1N1 influenza virus infected mice. Aloin-mediated inhibition of influe
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.
Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR. Tse LV, et al. J Virol. 2013 May;87(9):5161-9. doi: 10.1128/JVI.00210-13. Epub 2013 Feb 28. J Virol. 2013. PMID: 23449787 Free PMC article.
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. ...We further show that ce
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic clea
Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice.
Tate MD, Brooks AG, Reading PC. Tate MD, et al. J Immunol. 2011 Aug 15;187(4):1884-94. doi: 10.4049/jimmunol.1100295. Epub 2011 Jul 18. J Immunol. 2011. PMID: 21768397 Free article.
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by lectins of the innate immune system, including soluble surfactant protein-D and the macrophage mannose receptor on airway macrophages. ...A …
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by …
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection.
Kwon SJ, Na DH, Kwak JH, Douaisi M, Zhang F, Park EJ, Park JH, Youn H, Song CS, Kane RS, Dordick JS, Lee KB, Linhardt RJ. Kwon SJ, et al. Nat Nanotechnol. 2017 Jan;12(1):48-54. doi: 10.1038/nnano.2016.181. Epub 2016 Oct 24. Nat Nanotechnol. 2017. PMID: 27775724
Furthermore, the effectiveness of anti-influenza neuraminidase inhibitors has declined because of drug resistance. ...S3-G4 conjugates were resistant to hydrolysis by H1N1 neuraminidase. These conjugates protected 75% of mice from a lethal chall …
Furthermore, the effectiveness of anti-influenza neuraminidase inhibitors has declined because of drug resistance. ...S3-G4 co …
Residue 41 of the Eurasian avian-like swine influenza a virus matrix protein modulates virion filament length and efficiency of contact transmission.
Campbell PJ, Kyriakis CS, Marshall N, Suppiah S, Seladi-Schulman J, Danzy S, Lowen AC, Steel J. Campbell PJ, et al. J Virol. 2014 Jul;88(13):7569-77. doi: 10.1128/JVI.00119-14. Epub 2014 Apr 23. J Virol. 2014. PMID: 24760887 Free PMC article.
Position 41 of the influenza A virus matrix protein encodes a highly conserved alanine in human and avian lineages. ...In summary, we have identified a naturally occurring mutation in the influenza A virus matrix protein that impacts transmission effic …
Position 41 of the influenza A virus matrix protein encodes a highly conserved alanine in human and avian lineages. ...In summ …
A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Job ER, Bottazzi B, Short KR, Deng YM, Mantovani A, Brooks AG, Reading PC. Job ER, et al. J Immunol. 2014 Jan 1;192(1):271-81. doi: 10.4049/jimmunol.1301814. Epub 2013 Dec 4. J Immunol. 2014. PMID: 24307735 Free article.
The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating various aspects of the immune system. ...In this study, we demonstrate that specificity of both HA and the viral neuraminidase for part …
The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating va …
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