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H1N1 influenza A virus neuraminidase modulates infectivity in mice.
Ferraris O, Escuret V, Bouscambert M, Casalegno JS, Jacquot F, Raoul H, Caro V, Valette M, Lina B, Ottmann M. Ferraris O, et al. Antiviral Res. 2012 Mar;93(3):374-80. doi: 10.1016/j.antiviral.2012.01.008. Epub 2012 Feb 1. Antiviral Res. 2012. PMID: 22321413
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obtained b …
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on …
Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress.
Kwon EB, Li W, Kim YS, Kim B, Chung HS, Go Y, Ko HJ, Song JH, Kim YH, Choi CW, Choi JG. Kwon EB, et al. Acta Pharm Sin B. 2023 Jan;13(1):174-191. doi: 10.1016/j.apsb.2022.07.001. Epub 2022 Jul 6. Acta Pharm Sin B. 2023. PMID: 36815046 Free PMC article.
In addition, VB reduced body weight loss, increased survival, decreased viral replication and the inflammatory response in the lungs of influenza A virus (IAV)-infected mice. Taken together, our results indicate that VB is a promising therapeuti …
In addition, VB reduced body weight loss, increased survival, decreased viral replication and the inflammatory response in the lungs of i
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.
Liu Q, Xiong HR, Lu L, Liu YY, Luo F, Hou W, Yang ZQ. Liu Q, et al. Acta Pharmacol Sin. 2013 Aug;34(8):1075-83. doi: 10.1038/aps.2013.54. Epub 2013 Jun 17. Acta Pharmacol Sin. 2013. PMID: 23770981 Free PMC article.
In vitro cytotoxicity and antiviral activity of ARB was determined using MTT assay. BALB/c mice were infected with A/FM/1/47 (H1N1). Four hours later the mice were administered ARB (45, 90, and 180 mg.kg(-1).d(-1)) or the neuraminidase inhibitor …
In vitro cytotoxicity and antiviral activity of ARB was determined using MTT assay. BALB/c mice were infected with A/FM/1/47 ( …
Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.
Santos NB, Vaz da Silva ZE, Gomes C, Reis CA, Amorim MJ. Santos NB, et al. PLoS Pathog. 2021 Jul 1;17(7):e1009381. doi: 10.1371/journal.ppat.1009381. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34197564 Free PMC article.
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. ...However, the impact of modulating complement activation in viral infections is …
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate t …
Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase.
Broecker F, Zheng A, Suntronwong N, Sun W, Bailey MJ, Krammer F, Palese P. Broecker F, et al. J Virol. 2019 Aug 28;93(18):e00840-19. doi: 10.1128/JVI.00840-19. Print 2019 Sep 15. J Virol. 2019. PMID: 31375573 Free PMC article.
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). Anti-NA antibodies protect from lethal influenza virus challenge in the mouse model and correlate inversely with virus shedding and symptoms in humans. ...Similarly, ext …
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). Anti-NA antibodies protect fr …
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection.
Kwon SJ, Na DH, Kwak JH, Douaisi M, Zhang F, Park EJ, Park JH, Youn H, Song CS, Kane RS, Dordick JS, Lee KB, Linhardt RJ. Kwon SJ, et al. Nat Nanotechnol. 2017 Jan;12(1):48-54. doi: 10.1038/nnano.2016.181. Epub 2016 Oct 24. Nat Nanotechnol. 2017. PMID: 27775724
Rapid change and zoonotic transmission to humans have enhanced the virulence of the influenza A virus (IAV). Neutralizing antibodies fail to provide lasting protection from seasonal epidemics. ...S3-G4 conjugates were resistant to hydrolysis by H1N1
Rapid change and zoonotic transmission to humans have enhanced the virulence of the influenza A virus (IAV). Neutralizi …
Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice.
Tate MD, Brooks AG, Reading PC. Tate MD, et al. J Immunol. 2011 Aug 15;187(4):1884-94. doi: 10.4049/jimmunol.1100295. Epub 2011 Jul 18. J Immunol. 2011. PMID: 21768397
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by lectins of the innate immune system, including soluble surfactant protein-D and the macrophage mannose receptor on airway macrophage …
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recogni …
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.
Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR. Tse LV, et al. J Virol. 2013 May;87(9):5161-9. doi: 10.1128/JVI.00210-13. Epub 2013 Feb 28. J Virol. 2013. PMID: 23449787 Free PMC article.
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. Instead of the conventional trypsin-medi …
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of t …
Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza.
Huang CT, Hung CY, Hseih YC, Chang CS, Velu AB, He YC, Huang YL, Chen TA, Chen TC, Lin CY, Lin YC, Shih SR, Dutta A. Huang CT, et al. Phytomedicine. 2019 Nov;64:152904. doi: 10.1016/j.phymed.2019.152904. Epub 2019 Apr 4. Phytomedicine. 2019. PMID: 31454654
In vivo activity was tested in H1N1 influenza virus infected mice. Aloin-mediated inhibition of influenza neuraminidase activity was tested by MUNANA assay. ...In H1N1 influenza virus infected mice, aloin treatment (intraperitoneal …
In vivo activity was tested in H1N1 influenza virus infected mice. Aloin-mediated inhibition of influenza neuraminid
In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus.
Zhi HJ, Zhu HY, Zhang YY, Lu Y, Li H, Chen DF. Zhi HJ, et al. Phytomedicine. 2019 Apr;57:105-116. doi: 10.1016/j.phymed.2018.12.009. Epub 2018 Dec 10. Phytomedicine. 2019. PMID: 30668313
PURPOSE: To evaluate the therapeutic effects and action mechanism of flavonoids-enriched extract from S. baicalensis root (FESR) on acute lung injury (ALI) induced by influenza A virus (IAV) in mice. METHODS: The anti-influenza, anti-inflammatory and a …
PURPOSE: To evaluate the therapeutic effects and action mechanism of flavonoids-enriched extract from S. baicalensis root (FESR) on acute lu …
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