H1N1 influenza A virus neuraminidase modulates infectivity in mice.
Antiviral Res. 2012.
PMID: 22321413
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H1N1 influenza A virus neuraminidase modulates infectivity in mice.
Antiviral Res. 2012 Mar;93(3):374-80. doi: 10.1016/j.antiviral.2012.01.008. Epub 2012 Feb 1.
Antiviral Res. 2012.
PMID: 22321413
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obtained b …
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on …
Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress.
Acta Pharm Sin B. 2023 Jan;13(1):174-191. doi: 10.1016/j.apsb.2022.07.001. Epub 2022 Jul 6.
Acta Pharm Sin B. 2023.
PMID: 36815046
Free PMC article.
In addition, VB reduced body weight loss, increased survival, decreased viral replication and the inflammatory response in the lungs of influenza A virus (IAV)-infected mice. Taken together, our results indicate that VB is a promising therapeuti …
In addition, VB reduced body weight loss, increased survival, decreased viral replication and the inflammatory response in the lungs of i …
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection.
Nat Nanotechnol. 2017 Jan;12(1):48-54. doi: 10.1038/nnano.2016.181. Epub 2016 Oct 24.
Nat Nanotechnol. 2017.
PMID: 27775724
Rapid change and zoonotic transmission to humans have enhanced the virulence of the influenza A virus (IAV). Neutralizing antibodies fail to provide lasting protection from seasonal epidemics. ...S3-G4 conjugates were resistant to hydrolysis by H1N1 …
Rapid change and zoonotic transmission to humans have enhanced the virulence of the influenza A virus (IAV). Neutralizi …
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.
Acta Pharmacol Sin. 2013 Aug;34(8):1075-83. doi: 10.1038/aps.2013.54. Epub 2013 Jun 17.
Acta Pharmacol Sin. 2013.
PMID: 23770981
Free PMC article.
In vitro cytotoxicity and antiviral activity of ARB was determined using MTT assay. BALB/c mice were infected with A/FM/1/47 (H1N1). Four hours later the mice were administered ARB (45, 90, and 180 mg.kg(-1).d(-1)) or the neuraminidase inhibitor …
In vitro cytotoxicity and antiviral activity of ARB was determined using MTT assay. BALB/c mice were infected with A/FM/1/47 ( …
Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.
PLoS Pathog. 2021 Jul 1;17(7):e1009381. doi: 10.1371/journal.ppat.1009381. eCollection 2021 Jul.
PLoS Pathog. 2021.
PMID: 34197564
Free PMC article.
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. ...We found that DAF modulates IAV infection in vivo, via an interplay with the a …
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate t …
Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase.
J Virol. 2019 Aug 28;93(18):e00840-19. doi: 10.1128/JVI.00840-19. Print 2019 Sep 15.
J Virol. 2019.
PMID: 31375573
Free PMC article.
Two recombinant influenza viruses based on the H1N1 strain A/Puerto Rico/8/1934 (PR8) were rescued with NA stalk domains extended by 15 or 30 amino acids. ...Similarly, extending the stalk domain of the NA of a recent H3N2 virus enhanced the induction of anti-NA IgGs in …
Two recombinant influenza viruses based on the H1N1 strain A/Puerto Rico/8/1934 (PR8) were rescued with NA stalk domains extended by …
Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice.
J Immunol. 2011 Aug 15;187(4):1884-94. doi: 10.4049/jimmunol.1100295. Epub 2011 Jul 18.
J Immunol. 2011.
PMID: 21768397
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by lectins of the innate immune system, including soluble surfactant protein-D and the macrophage mannose receptor on airway macrophage …
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recogni …
Integrated In Silico, In Vitro, and In Vivo Studies Reveal Mangiferin as a Promising Antiviral Agent Against H1N1/pdm2009 Influenza Virus.
Viruses. 2025 Jun 21;17(7):873. doi: 10.3390/v17070873.
Viruses. 2025.
PMID: 40733492
Free PMC article.
The ongoing global threat posed by the influenza A virus, exacerbated by antigenic drift and the emergence of antiviral resistance, accentuates the urgent need for innovative therapeutic strategies. Through molecular docking, this study revealed that mangifer …
The ongoing global threat posed by the influenza A virus, exacerbated by antigenic drift and the emergence of antiviral …
In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus.
Phytomedicine. 2019 Apr;57:105-116. doi: 10.1016/j.phymed.2018.12.009. Epub 2018 Dec 10.
Phytomedicine. 2019.
PMID: 30668313
PURPOSE: To evaluate the therapeutic effects and action mechanism of flavonoids-enriched extract from S. baicalensis root (FESR) on acute lung injury (ALI) induced by influenza A virus (IAV) in mice. METHODS: The anti-influenza, anti-inflammatory and a …
PURPOSE: To evaluate the therapeutic effects and action mechanism of flavonoids-enriched extract from S. baicalensis root (FESR) on acute lu …
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.
J Virol. 2013 May;87(9):5161-9. doi: 10.1128/JVI.00210-13. Epub 2013 Feb 28.
J Virol. 2013.
PMID: 23449787
Free PMC article.
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. Instead of the conventional trypsin-medi …
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of t …
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