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H1N1 influenza A virus neuraminidase modulates infectivity in mice.
Ferraris O, Escuret V, Bouscambert M, Casalegno JS, Jacquot F, Raoul H, Caro V, Valette M, Lina B, Ottmann M. Ferraris O, et al. Antiviral Res. 2012 Mar;93(3):374-80. doi: 10.1016/j.antiviral.2012.01.008. Epub 2012 Feb 1. Antiviral Res. 2012. PMID: 22321413
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obt …
We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on …
Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress.
Kwon EB, Li W, Kim YS, Kim B, Chung HS, Go Y, Ko HJ, Song JH, Kim YH, Choi CW, Choi JG. Kwon EB, et al. Acta Pharm Sin B. 2023 Jan;13(1):174-191. doi: 10.1016/j.apsb.2022.07.001. Epub 2022 Jul 6. Acta Pharm Sin B. 2023. PMID: 36815046 Free PMC article.
The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral therapeutics. ...In addition, VB reduced body weight loss, increased survival, decreased viral replication and the inflammatory response in the lungs of …
The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral therapeutics. …
Nanostructured glycan architecture is important in the inhibition of influenza A virus infection.
Kwon SJ, Na DH, Kwak JH, Douaisi M, Zhang F, Park EJ, Park JH, Youn H, Song CS, Kane RS, Dordick JS, Lee KB, Linhardt RJ. Kwon SJ, et al. Nat Nanotechnol. 2017 Jan;12(1):48-54. doi: 10.1038/nnano.2016.181. Epub 2016 Oct 24. Nat Nanotechnol. 2017. PMID: 27775724
Furthermore, the effectiveness of anti-influenza neuraminidase inhibitors has declined because of drug resistance. ...S3-G4 conjugates were resistant to hydrolysis by H1N1 neuraminidase. These conjugates protected 75% of mice from a lethal chall …
Furthermore, the effectiveness of anti-influenza neuraminidase inhibitors has declined because of drug resistance. ...S3-G4 co …
Complement Decay-Accelerating Factor is a modulator of influenza A virus lung immunopathology.
Santos NB, Vaz da Silva ZE, Gomes C, Reis CA, Amorim MJ. Santos NB, et al. PLoS Pathog. 2021 Jul 1;17(7):e1009381. doi: 10.1371/journal.ppat.1009381. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34197564 Free PMC article.
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the pathogen without causing immunopathology. ...However, the impact of modulating complement activation in viral infections is still …
Clearance of viral infections, such as SARS-CoV-2 and influenza A virus (IAV), must be fine-tuned to eliminate the path …
Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection.
Liu Q, Xiong HR, Lu L, Liu YY, Luo F, Hou W, Yang ZQ. Liu Q, et al. Acta Pharmacol Sin. 2013 Aug;34(8):1075-83. doi: 10.1038/aps.2013.54. Epub 2013 Jun 17. Acta Pharmacol Sin. 2013. PMID: 23770981 Free PMC article.
AIM: To investigate the effects of arbidol hydrochloride (ARB), a widely used antiviral agent, on the inflammation induced by influenza virus. METHODS: MDCK cells were infected with seasonal influenza A/FM/1/47 (H1N1) or pandemic influenza
AIM: To investigate the effects of arbidol hydrochloride (ARB), a widely used antiviral agent, on the inflammation induced by influenza
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin is independent of the viral neuraminidase.
Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR. Tse LV, et al. J Virol. 2013 May;87(9):5161-9. doi: 10.1128/JVI.00210-13. Epub 2013 Feb 28. J Virol. 2013. PMID: 23449787 Free PMC article.
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic cleavage site of the viral hemagglutinin (HA), which activates HA and exposes the fusion peptide for membrane fusion. ...We further show that ce
Influenza virus is well recognized to modulate host tropism and pathogenesis based on mutations in the proteolytic clea
Extending the Stalk Enhances Immunogenicity of the Influenza Virus Neuraminidase.
Broecker F, Zheng A, Suntronwong N, Sun W, Bailey MJ, Krammer F, Palese P. Broecker F, et al. J Virol. 2019 Aug 28;93(18):e00840-19. doi: 10.1128/JVI.00840-19. Print 2019 Sep 15. J Virol. 2019. PMID: 31375573 Free PMC article.
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). ...Our findings may assist in the efforts toward more effective influenza virus vaccines....
Influenza viruses express two surface glycoproteins, the hemagglutinin (HA) and the neuraminidase (NA). ...Our findings may as
In vivo effect of quantified flavonoids-enriched extract of Scutellaria baicalensis root on acute lung injury induced by influenza A virus.
Zhi HJ, Zhu HY, Zhang YY, Lu Y, Li H, Chen DF. Zhi HJ, et al. Phytomedicine. 2019 Apr;57:105-116. doi: 10.1016/j.phymed.2018.12.009. Epub 2018 Dec 10. Phytomedicine. 2019. PMID: 30668313
Mice were challenged intranasally with influenza virus H1N1 (A/FM/1/47) 2 h before treatment. ...FESR efficiently decreased lung virus titers, reduced haemagglutinin (HA) titers and inhibited neuraminidase (NA) activities in lungs of IAV-
Mice were challenged intranasally with influenza virus H1N1 (A/FM/1/47) 2 h before treatment. ...FESR efficientl
Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice.
Tate MD, Brooks AG, Reading PC. Tate MD, et al. J Immunol. 2011 Aug 15;187(4):1884-94. doi: 10.4049/jimmunol.1100295. Epub 2011 Jul 18. J Immunol. 2011. PMID: 21768397
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by lectins of the innate immune system, including soluble surfactant protein-D and the macrophage mannose receptor on airway macrophages. ...A …
Oligosaccharides on the hemagglutinin (HA) and neuraminidase of influenza A virus (IAV) are a target for recognition by …
A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Job ER, Bottazzi B, Short KR, Deng YM, Mantovani A, Brooks AG, Reading PC. Job ER, et al. J Immunol. 2014 Jan 1;192(1):271-81. doi: 10.4049/jimmunol.1301814. Epub 2013 Dec 4. J Immunol. 2014. PMID: 24307735
The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating various aspects of the immune system. ...In this study, we demonstrate that specificity of both HA and the viral neuraminidase for part …
The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental roles during infection and disease by modulating va …
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