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H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Zhao D, Zhang Q, Liu Y, Li X, Zhao K, Ding Y, Li Z, Shen Q, Wang C, Li N, Cao X. Zhao D, et al. Cell Rep. 2020 Feb 18;30(7):2460. doi: 10.1016/j.celrep.2020.01.104. Cell Rep. 2020. PMID: 32075775 Free article. No abstract available.
H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Zhao D, Zhang Q, Liu Y, Li X, Zhao K, Ding Y, Li Z, Shen Q, Wang C, Li N, Cao X. Zhao D, et al. Cell Rep. 2016 Apr 12;15(2):288-99. doi: 10.1016/j.celrep.2016.03.035. Epub 2016 Mar 31. Cell Rep. 2016. PMID: 27050510 Free article.
Mechanistic studies reveal that Kdm5a associates with p50 and binds to the Socs1 promoter region in resting NK cells, leading to a substantial decrease in H3K4me3 modification and repressive chromatin configuration at the Socs1
Mechanistic studies reveal that Kdm5a associates with p50 and binds to the Socs1 promoter region in resting N
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